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Table I.
Susceptibility of F. johnsoniae G873 to antimicrobial agents in the absence and presence of the efflux pump inhibitor PaβN.
| Class | MIC (μg/mL) |
||
|---|---|---|---|
| Antimicrobial agent | MIC plate dilution range (μg/mL) | 0 μg/mL PaβN | 20 μg/mL PaβN |
| Penicillin | |||
| Ampicillin | GPN2F (0.12–16) | 16 | 8 |
| Ampicillin/sulbactam | GN2F (4/2–32/16) | 16/8 | 8/4 |
| Oxacillin + 2% NaCl | GPN2F (0.25–8) | 0.25 | 0.25 |
| Penicillin | GPN2F (0.06–8) | 8 | 4 |
| Cephem | |||
| Cefazolin | GN2F (4–32) | > 32 | > 32 |
| Cefepime | GN2F (4–32) | 8 | 8 |
| Ceftazidime | GN2F (1–32) | > 32 | > 32 |
| Macrolide | |||
| Erythromycin | GPN2F (0.25–8) | 4 | 0.5* |
| Clarithromycin | GPN2F (1–8) | 1 | 1 |
| Monobactam | |||
| Aztreonam | GN2F (8–32) | > 32 | > 32 |
| Lincosamide | |||
| Clindamycin | GPN2F (0.5–4) | 0.5 | 0.5 |
| Fluoroquinolone | |||
| Levofloxacin | GPN2F (0.25–8) | 1 | 0.25* |
| Oxazolidinone | |||
| Linezolid | GPN2F (0.5–8) | 4 | 1* |
| Streptogramin | |||
| Quinupristin/dalfopristin | GPN2F (0.25–4) | > 4 | 4 |
| Ansamycin | |||
| Rifampin | GPN2F (0.5–4) | 0.5 | 0.5 |
| Tetracycline | |||
| Tetracycline | GPN2F (2–16) | 2 | 2 |
| Aminoglycoside | |||
| Amikacin | Dilution assay | 140 | 100 |
| Gentamicin | Dilution assay | 140 | 100 |
| Kanamycin | Dilution assay | 450 | 400 |
| Streptomycin | Dilution assay | 64 | 32 |
| Phenicol | |||
| Chloramphenicol | Dilution assay | 16 | 4* |
| Florfenicol | Dilution assay | 16 | 4* |
| Flouroquinolone | |||
| Nalidixic acid | Dilution assay | 140 | 140 |
| Norfloxacin | Dilution assay | 4 | 1* |