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Table II.
Changes in gene expression relative to uninfected controls within each intestinal section at 1, 2 and 6 dpi. Only genes with statistically significant changes are shown.
Jejunum fold-changea | Ileum fold-changea | Colon fold-changea | Jejunum fold-changea | Ileum fold-changea | Colon fold-changea | |||
---|---|---|---|---|---|---|---|---|
IL-8 | TLR-2 | |||||||
1 dpi | 3.54 ** | 5.29 ** | 1.23 | 1 dpi | −1.44 | 3.59 ** | −1.59 | |
2 dpi | 8.43 ** | 5.59 ** | 3.53 ** | 2 dpi | 1.34 | 2.56 * | 1.08 | |
6 dpi | 3.31 | 3.61 | 3.30 ** | 6 dpi | −3.31 * | 5.58 ** | −1.2 | |
MCP-1 | TLR-3 | |||||||
1 dpi | 2.27 | 4.80 ** | −1.37 | 1 dpi | −1.44 | −2.35 * | −2.37 | |
2 dpi | 2.77 * | 3.59 * | 1.25 | 2 dpi | 1.2 | −2.21 | −1.60 | |
6 dpi | −1.06 | 1.62 | 1.11 | 6 dpi | 1.27 | 1.22 | −3.09 * | |
MIP-1α | TLR-5 | |||||||
1 dpi | 2.19 | 1.6 | −1.01 | 1 dpi | −1.12 | −2.05 | −1.97 | |
2 dpi | 3.86 * | 3.84 ** | 1.64 | 2 dpi | −1.14 | −2.22 | −1.53 | |
6 dpi | 1.76 | 3.58 * | 4.52 ** | 6 dpi | −1.51 | −1.10 | −2.39 * | |
MIP-1β | TLR-9 | |||||||
1 dpi | 1.73 | 1.88 | −1.27 | 1 dpi | −1.02 | −1.35 | 1.45 | |
2 dpi | 2.65 * | 1.87 | −1.12 | 2 dpi | 1.67 | −1.11 | 3.06 * | |
6 dpi | −1.26 | 2.79 * | 2.1 | 6 dpi | 1.3 | −2.93 * | 1.41 | |
TNF-α | TLR-10 | |||||||
1 dpi | 2.59 | 2.86 * | 1.02 | 1 dpi | −1.09 | −2.24 | 1.09 | |
2 dpi | 3.59 ** | 1.95 | 2.22 * | 2 dpi | −1.43 | −1.79 | 1.34 | |
6 dpi | 1.65 | 1.48 | 1.48 | 6 dpi | 1.21 | −2.73 * | −1.65 | |
IL-1β | NOD1 | |||||||
1 dpi | 1.72 | 1.46 | −1.22 | 1 dpi | 2.34 | 2.85 * | 1.15 | |
2 dpi | 15.38 ** | 1.02 | 3.09 * | 2 dpi | 5.86 ** | 2.97 * | 1.57 | |
6 dpi | −3.48 ** | −5.02** | 3.33 ** | 6 dpi | 1.77 | 1.75 | 1.43 | |
IFN-γ | NOD2 | |||||||
1 dpi | 1.36 | 1.9 | −1.21 | 1 dpi | 1.96 | 1.17 | −1.04 | |
2 dpi | 2.87 ** | −1.35 | 1.31 | 2 dpi | 3.05 * | 1.17 | 1.18 | |
6 dpi | −2.14 | 1.46 | 3.61 ** | 6 dpi | −1.31 | −1.13 | −1.31 | |
IL-6 | NF- κ B | |||||||
1 dpi | 2.09 | 2.1 | 1.07 | 1 dpi | 1.03 | 1.97 | 1.07 | |
2 dpi | 5.43 ** | −1.32 | 2.89 * | 2 dpi | 1.1 | 3.43 * | −1.41 | |
6 dpi | −1.98 | -4.00 ** | 2.23 | 6 dpi | −1.65 | 2.28 * | −1.44 | |
IL-12p40 | Caspase-1 | |||||||
1 dpi | 1.32 | −1.49 | −1.69 | 1 dpi | 1.31 | −2.51 * | −1.07 | |
2 dpi | 1.05 | −4.36 ** | 1.58 | 2 dpi | 1.42 | −2.60 * | −1.14 | |
6 dpi | −3.03 * | −4.61 ** | 2.44 * | 6 dpi | 1.26 | 1.09 | −1.35 | |
TLR-1 | PBD-2 | |||||||
1 dpi | −1.25 | −2.12 | −1.73 | 1 dpi | −19.56 ** | 2.95 * | 1.02 | |
2 dpi | −2.23 * | 1.1 | −1.08 | 2 dpi | −17.21 ** | 6.97 ** | 2.34 | |
6 dpi | −1.1 | −1.59 | −1.67 | 6 dpi | −18.30 ** | 1.1 | −1.22 |