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Review
Table I.
Summary table to show experimental design variation and protection from clinical disease in cattle following vaccination with FMD vaccines formulated for emergency use.
| Breed | Vaccine | Challenge | Days vaccinated before exposure |
Ref. | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 0 | 2 | 3 | 4 | 5 | 7 | 8 | 10 | 12 | 14 | 16 | 21 | ||||
| Hereford | A119a 10 μg/dosec Oild |
Homologous direct contact with 2 infectious cattle (for 10 days?) |
0/5 | 4/4b | 3/4 | 4/4 | 4/4 | 4/4 | [38] | ||||||
| Aberdeen Angus Friesian cross |
O1 BFS 1860 10 μg/dose Aqueous |
Homologous indirect aerosol from 2 infectious pigs for 1 h |
0/12 | 3/6 | 3/6 | 6/6 | 18/18 | [29] | |||||||
| Friesian and Friesian Hereford cross |
O1 Lausanne 4.1 μg/dose Aqueous |
Homologous indirect aerosol from 3 infectious pigs for 1 h |
0/2 | 2/2 | 3/3 | 3/3 | 3/3 | 3/3 | [25] | ||||||
| O1 Lausanne 4.1 μg/dose Oil |
2/2 | 3/3 | 3/3 | 3/3 | 3/3 | ||||||||||
| Friesian and Friesian Hereford cross |
C1 Oberbayern 1.9 μg/dose Aqueous |
Homologous indirect aerosol from 3 infectious pigs for 1 h |
0/2 | 2/2 | 3/3 | 3/3 | 3/3 | 3/3 | [25] | ||||||
| C1 Oberbayern 1.9 μg/dose oil |
2/2 | 3/3 | 3/3 | 3/3 | 3/3 | ||||||||||
|
e Friesian Hereford cross ? |
Asia 1 India 8/79 4.8 μg/dose Aqueous |
Homologous indirect aerosol from 3 infectious pigs for 1 h |
0/2 | 0/3 | 3/3 | 2/3 | 3/3 | 2/2 | See footnote 1 |
||||||
| Asia 1 India 8/79 4.8 μg/dose Oil |
3/3 | 3/3 | 6/6 | 6/6 | 4/4 | ||||||||||
| Holstein Friesian cross |
O1 Manisa ? (18 PD50) 1× payload Oil |
Semi-heterologous direct contact with 5 infectious cattle for 5 days |
0/10 | 15/20 | 20/20 | [21, 23] | |||||||||
| O1 Manisa ? (18 PD50) 10× payload Oil |
0/10 | 14/20 | 20/20 | [22, 23] | |||||||||||