Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs

Phaedra Eblé; Aline de Koeijer; Annemarie Bouma; Arjan Stegeman; Aldo Dekker

doi:doi:10.1051/vetres:2006026

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Volume 37 / No 5 (September-October 2006)

Vet. Res., 37 5 (2006) 647-654

Abstract

Free Access

Issue		Vet. Res. Volume 37, Number 5, September-October 2006


Page(s)		647 - 654
DOI		https://doi.org/10.1051/vetres:2006026
Published online		17 June 2006
How to cite this article		Vet. Res. (2006) 647-654

Vet. Res. 37 (2006) 647-654
DOI: 10.1051/vetres:2006026

Quantification of within- and between-pen transmission of Foot-and-Mouth disease virus in pigs

Phaedra Eblé^a, Aline de Koeijer^b, Annemarie Bouma^c, Arjan Stegeman^c and Aldo Dekker^a

^a Central Institute for Animal Disease Control (CIDC-Lelystad), PO Box 2004, 8203 AA Lelystad, The Netherlands
^b Division of Infectious Diseases, Animal Sciences Group Wageningen UR, PO Box 65, 8200 AB Lelystad, The Netherlands
^c Department of Farm Animal Health, Faculty of Veterinary Medicine, Utrecht University, Yalelaan 7, 3584 CL Utrecht, The Netherlands

(Received 17 October 2005; accepted 1 March 2006; published online 17 June 2006)

Abstract - Quantified transmission parameters of Foot-and-Mouth Disease Virus (FMDV) are needed for epidemic models used for control and surveillance. In this study, we quantified the within- and between-pen transmission of FMDV in groups of pigs by estimating the daily transmission rate $\beta$ , i.e. the number of secondary infections caused by one infectious pig during one day, using an SIR (susceptible-infectious-removed) model. Within-pen transmission was studied in four groups of ten pigs in which 5 infected and 5 susceptible pigs had direct contact; between-pen transmission was studied in one group of ten pigs in which 5 infected and 5 susceptible pigs had indirect contact. Daily results of virus isolation of oropharyngeal fluid were used to quantify the transmission rate $\beta$ , using Generalised Linear Modelling (GLM) and a maximum likelihood method. In addition, we estimated the expected time to infection of the first pig within a pen T_w and in the indirect-contact pen T_b. The between-pen transmission rate $\beta$ _b was estimated to be 0.59 (0.083-4.18) per day, which was significantly lower than the within-pen transmission rate $\beta$ _w of 6.14 (3.75-10.06). T_w was 1.6 h, and T_b was 16 h. Our results show that the transmission rate is influenced by contact structure between pigs.

Key words: foot-and-mouth disease / pigs / transmission / transmission rate / modelling

Corresponding author: phaedra.eble@wur.nl

© INRA, EDP Sciences 2006