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Vet. Res.
Volume 32, Number 3-4, May-August 2001
Mechanisms of resistance to antibiotics in animal and zoonotic pathogens
Page(s) 291 - 300
How to cite this article Vet. Res. (2001) 291-300
DOI: 10.1051/vetres:2001105

Vet. Res. 32 (2001) 291-300

Mechanisms of quinolone resistance in Salmonella

Axel Cloeckaert and Elisabeth Chaslus-Dancla

Station de Pathologie Aviaire et Parasitologie, Institut National de la Recherche Agronomique, 37380 Nouzilly, France

(Received 20 February 2001; accepted 16 March 2001)

As in other Gram-negative bacteria, mechanisms of resistance to quinolones in Salmonella include target gene mutations, active efflux, and decreased outer membrane permeability. However, the exact contribution of these individual mechanisms to resistance, which may nevertheless interplay to reach high-level resistance, has not yet clearly been defined as in other bacteria such as Escherichia coli. This paper reviews the current state of knowledge of quinolone resistance mechanisms in Salmonella by comparison with that of E. coli and future directions of research with particular attention to the recent development of efflux pump inhibitors as possible means of avoiding the emergence and spread of fluoroquinolone resistance.

Mécanismes de résistance aux quinolones chez Salmonella. Comme chez les autres bactéries Gram-négatives les mécanismes de résistance aux quinolones chez Salmonella comprennent les mutations dans les gènes cibles, l'efflux actif, et une diminution de la perméabilité de la membrane externe. Cependant la contribution exacte de ces mécanismes individuels, qui peuvent néanmoins interagir pour atteindre des niveaux de résistance élevés, n'a pas encore été clairement définie comme chez d'autres bactéries telle que Escherichia coli. Cette revue présente l'état actuel des connaissances des mécanismes de résistance chez Salmonella par comparaison avec E. coli et des perspectives futures de recherche avec une attention particulière au développement récent d'inhibiteurs de pompes d'efflux comme moyen possible pour éviter l'émergence et la diffusion de la résistance aux fluoroquinolones.

Key words: Salmonella / quinolone / resistance / mechanism

Mots clés : Salmonella / quinolone / résistance / mécanisme

Correspondence and reprints: Axel Cloeckaert Tel.: (33) 2 47 42 77 50; fax: (33) 2 47 42 77 74;

© INRA, EDP Sciences 2001

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