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Vet. Res.
Volume 32, Number 3-4, May-August 2001
Mechanisms of resistance to antibiotics in animal and zoonotic pathogens
Page(s) 201 - 225
How to cite this article Vet. Res. (2001) 201-225
  1. Aires J.R., Köhler T., Nikaido H., Plésiat P., Involvement of an active efflux system in the natural resistance of Pseudomonas earuginosa to aminoglycosides, Antimicrob. Agents Chemother. 43 (1999) 2624-2628 [PubMed].
  2. Alekshun M.N., Levy S.B., Bacterial drug resistance: response to survival threats, in: Storz G., Hengge-Aronis R. (Eds.), Bacterial stress responses, ASM Press, Washington D.C., 2000, pp. 323-366.
  3. Arcangioli M.-A., Leroy-Sétrin S., Martel J.-L., Chaslus-Dancla E., A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104, FEMS Microbiol. Lett. 174 (1999) 327-324 [PubMed].
  4. Bager F., Helmuth R., Epidemiology of quinolone resistance in Salmonella, Vet. Res. 32 (2001) 285-290 [CrossRef] [PubMed] [EDP Sciences].
  5. Bennett P.M., The spread of drug resistance, in: Baumberg S., Young J.P.W., Wellington E.M.H., Saunders J.R. (Eds.), Population genetics in bacteria, University Press, Cambridge, 1995, pp. 317-344.
  6. Boatman M., Survey of antimicrobial usage in animal health in the European union, Boatman consulting, Sept. 1998, by order of FEDESA.
  7. Bories G., Louisot P., Rapport concernant l'utilisation d'antibiotiques comme facteurs de croissance en alimentation, Rapport présenté au Ministère de l'Agriculture, de la Pêche et de l'Alimentation, 1998, 23 p.
  8. Briggs C.E., Fratamico P.M., Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104, Antimicrob. Agents Chemother. 43 (1999) 846-849 [PubMed].
  9. Bush K., Jacoby G.A., Medeiros A.A., A functional classification scheme for $\beta$-lactamases and its correlation with molecular structure, Antimicrob. Agents Chemother. 39 (1995) 1211-1233 [PubMed].
  10. Carattoli A., Importance of integrons in the diffusion of resistance, Vet. Res. 32 (2001) 243-259 [CrossRef] [PubMed] [EDP Sciences].
  11. Charpentier E., Courvalin P., Emergence of the trimethoprim resistance gene dfrD in Listeria monocytogenes BM4293, Antimicrob. Agents Chemother. 41 (1997) 1124-1136 [PubMed].
  12. Chaslus-Dancla E., Martel J.L., Carlier C., Lafont J.P., Courvalin P., Emergence of aminoglycoside 3-N-acetyltransferase IV in Escherichia coli and Salmonella typhimurium isolated from animals in France, Antimicrob. Agents Chemother. 29 (1986) 239-243 [PubMed].
  13. Chaslus-Dancla E., Glupczynski Y., Gerbaud G., Lagorce M., Lafont J.P., Detection of apramycin resistant Enterobacteriaceae in hospital isolates, FEMS Microbiol. Lett. 52 (1989) 261-265 [PubMed].
  14. Chaslus-Dancla E., Pohl P., Meurisse M., Marin M., Lafont J.P., High genetic homology between plasmids of human and animal origins conferring resistance to the aminoglycosides gentamicin and apramycin, Antimicrob. Agents Chemother. 35 (1991) 590-593 [PubMed].
  15. Chung W.O., Werckenthin C., Schwarz S., Roberts M.C., Host range of the ermF rRNA methylase gene in human and animal bacteria, J. Antimicrob. Chemother. 43 (1999) 5-14 [CrossRef].
  16. Cloeckaert A., Chaslus-Dancla E., Mechanisms of quinolone resistance in Salmonella, Vet. Res. 32 (2001) 291-300 [CrossRef] [PubMed] [EDP Sciences].
  17. Cloeckaert A., Baucheron S., Flaujac G., Schwarz S., Kehrenberg C., Martel J.-L., Chaslus-Dancla E., Plasmid-mediated florfenicol resistance encoded by the floR gene in Escherichia coli isolated from cattle, Antimicrob. Agents Chemother. 44 (2000) 2858-2860 [CrossRef] [PubMed].
  18. Cloeckaert A., Sidi Boumedine K., Flaujac G., Imbrechts H., D'Hooghe I., Chaslus-Dancla E., Occurrence of a Salmonella enterica serovar Typhimurium DT104-like antibiotic resistance gene cluster including the floR gene in S. enterica serovar Agona, Antimicrob. Agents Chemother. 44 (2000) 1359-1361 [CrossRef] [PubMed].
  19. Davies J., Inactivation of antibiotics and the dissemination of resistance genes, Science 264 (1994) 375-381 [CrossRef].
  20. Davies J., Wright G.D., Bacterial resistance to aminoglycoside antibiotics, Trends Microbiol. 5 (1997) 375-382 [CrossRef].
  21. Elwell L.P., Fling M.E., Resistance to trimethoprim, in: Bryan L.E. (Ed.), Microbial Resistance to Drugs, Springer Verlag, Berlin, 1989, pp. 249-290.
  22. European Agency for the Evaluation of Medical Products (EMEA), Antibiotic resistance in the European union associated with therapeutic use of veterinary medicines. Report and qualitative risk assessment, by the committee for veterinary medicinal products, 1999 (
  23. Everett M.J., Piddock L.J.V., Mechanisms of resistance to fluoroquinolones, in: Kuhlmann J., Dalhoff A., Zeiler H.-J. (Eds.), Quinolone antibacterials, Springer Verlag Berlin Heidelberg, 1998, pp. 259-296.
  24. Georgeopapadakou N.H., Penicillin-binding proteins and bacterial resistance to $\beta$-lactams, Antimicrob. Agents Chemother. 37 (1993) 2045-2053 [PubMed].
  25. Giraud E., Cloeckaert A., Kerboeuf D., Chaslus-Dancla E., Evidence for active efflux as the primary mechanism of resistance to ciprofloxacin in Salmonella enterica serovar Typhimurium, Antimicrob. Agents Chemother. 44 (2000) 1223-1228 [CrossRef] [PubMed].
  26. Hackbarth C.J., Chambers H.F., Methicillin-resistant staphylococci: genetics and mechanism of resistance, Antimicrob. Agents Chemother. 33 (1989) 991-994 [PubMed].
  27. Hooper D.C., Mechanisms of fluoroquinolone resistance, Drug Res. Updates 2 (1999) 38-55.
  28. Hooper D.C., Wolfson J.S., Bozza M.A., Ng E.Y., Genetics and regulation of outer protein expression by quinolone resistance loci nfxB, nfxC, and cfxB, Antimicrob. Agents Chemother. 36 (1992) 1151-1154 [PubMed].
  29. Huovinen P., Sundström L., Swedberg G., Sköld O., Trimethoprim and sulfonamide resistance, Antimicrob. Agents Chemother. 39 (1995) 279-289 [PubMed].
  30. Jones M.E., Sahm D.F., Martin N., Scheuring S., Heisig P., Thornsberry C., Köhrer K., Schmitz F.-J., Prevalence of gyrA, gyrB, parC, and parE mutations in clinical isolates of Streptococcus pneumoniae with decreased susceptibilities to different fluoroquinolones and originating from worldwide surveillance studies during the 1997-1998 respiratory season, Antimicrob. Agents Chemother. 44 (2000) 462-466 [CrossRef] [PubMed].
  31. Katayama Y., Ito T., Hiramatsu K., A new class of genetic element, Staphylococcus cassette chromosome mec, encodes methicillin resistance in Staphylococcus aureus, Antimicrob. Agents Chemother. 44 (2000) 1549-1555 [CrossRef] [PubMed].
  32. Keyes K., Hudson C., Maurer J.J., Thayer S., White D.G., Lee M.D., Detection of florfenicol resistance genes in Escherichia coli isolated from sick chickens, Antimicrob. Agents Chemother. 44 (2000) 421-424 [CrossRef] [PubMed].
  33. Kim E.H., Aoki T., Sequence analysis of the florfenicol resistance gene encoded on the transferable R-plasmid of a fish pathogen, Pasteurella piscicida, Microbiol. Immunol. 40 (1996) 665-669 [PubMed].
  34. Kokjohn T.A., Transduction: Mechanism and potential for gene transfer in the environment, in: Levy S.B., Miller R.V. (Eds.), Gene transfer in the environment, McGraw-Hill, New York, 1989, pp. 73-97.
  35. Leclercq R., Courvalin P., Bacterial resistance to macrolide, lincosamide, and streptogramin antibiotics by target modification, Antimicrob. Agents Chemother. 35 (1991) 1267-1272 [PubMed].
  36. Leclercq R., Courvalin P., Intrinsic and unusual resistance to macrolide, lincosamide, and streptogramin antibiotics in bacteria, Antimicrob. Agents Chemother. 35 (1991) 1273-1276 [PubMed].
  37. Levy S.B., Mcmurry L.M., Barbosa T.M., Burdett V., Courvalin P., Hillen W., Roberts M.C., Rood J.I., Taylor D.E., Nomenclature for new tetracycline resistance determinants, Antimicrob. Agents Chemother. 43 (1999) 1523-1524 [PubMed].
  38. Livermore D.M., $\beta$-Lactamases in laboratory and clinical resistance, Clin. Microbiol. Rev. 8 (1995) 557-584 [PubMed].
  39. Lovett P.S., Translational attenuation as the regulator of inducible cat genes, J. Bacteriol. 172 (1996) 1-6.
  40. Meier A., Kirschner P., Burkhardt S., Steingrube V.A., Brown B.A., Wallace Jr. R.J., Böttger E.C., Identification of mutations in 23S rRNA gene of clarithromycin-resistant Mycobacterium intracellulare, Antimicrob. Agents Chemother. 38 (1994) 381-384 [PubMed].
  41. Mingeot-Leclercq M.-P., Glupczynski Y., Tulkens P.M., Aminoglycosides: activity and resistance, Antimicrob. Agents Chemother. 43 (1999) 727-737 [PubMed].
  42. Murray I.A., Shaw W.V., O-acetyltransferases for chloramphenicol and other natural products, Antimicrob. Agents Chemother. 41 (1997) 1-6 [PubMed].
  43. Oethinger M., Kern W.V., Jellen-Ritter A.S., McMurry L.M., Levy S.B., Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pump, Antimicrob. Agents Chemother. 44 (2000) 10-13 [PubMed].
  44. Paulsen I.T., Brown M.H., Skurray R.A., Proton-dependent multidrug efflux systems, Microbiol. Rev. 60 (1996) 575-608 [PubMed].
  45. Poole K., Efflux-mediated resistance to fluoroquinolones in Gram-negative bacteria, Antimicrob. Agents Chemother. 44 (2000) 2233-2241 [CrossRef] [PubMed].
  46. Poole K., Efflux-mediated resistance to fluoroquinolones in Gram-positive bacteria and the mycobacteria, Antimicrob. Agents Chemother. 44 (2000) 2595-2599 [CrossRef] [PubMed].
  47. Putman M., van Veen H.W., Konings W.N., Molecular properties of bacterial multidrug transporters, Microbiol. Mol. Biol. Rev. 64 (2000) 672-693 [PubMed].
  48. Quintiliani R. Jr., Sahm D.F., Courvalin P., Mechanisms of resistance to antimicrobial agents, in: Murray P.R., Baron E.J., Pfaller M.A., Tenover F.C., Yolken R.H. (Eds.), Manual of Clinical Microbiology, 7th ed., ASM Press, Washington D.C., 1999, pp. 1505-1525.
  49. Radström P., Swedberg G., RSF1010 and a conjugative plasmid contain sulII, one of two known genes for plasmid-borne sulfonamide resistance dihydropteroate synthase, Antimicrob. Agents Chemother. 32 (1988) 1684-1692 [PubMed].
  50. Rasmussen J.L., Odelson D.A., Macrina F.L., Complete nucleotide sequence and transcription of ermF, a macrolide-lincosamide-streptogramin B resistance determinant from Bacteroides fragilis, J. Bacteriol. 168 (1986) 523-533 [PubMed].
  51. Recchia G.D., Hall R.M., Gene cassettes: a new class of mobile element, Microbiology 141 (1995) 3015-3027 [PubMed].
  52. Roberts M.C., Tetracycline resistance determinants: mechanisms of action, regulation of expression, genetic mobility, and distribution, FEMS Microbiol. Rev. 19 (1996) 1-24 [PubMed].
  53. Roberts M.C., Sutcliffe J., Courvalin P., Jensen L.B., Rood J., Seppälä H., Nomenclature for macrolide and macrolide-lincosamide-streptogramin B resistance determinants, Antimicrob. Agents Chemother. 43 (1999) 2823-2830 [PubMed].
  54. Rosenberg E., Ma D., Nikaido H., AcrD of Escherichia coli is an aminoglycoside efflux pump, J. Bacteriol. 182 (2000) 1754-1756 [CrossRef] [PubMed].
  55. Ross J.I., Eady E.A., Cove J.H., Baumberg S., Identification of a chromosomally encoded ABC-transport system with which the staphylococcal erythromycin exporter MsrA may interact, Gene 153 (1995) 93-98 [CrossRef] [PubMed].
  56. Ross J.I., Eady E.A., Cove J.H., Cunliffe W.J., 16S rRNA mutation associated with tetracycline resistance in a Gram-positive bacterium, Antimicrob. Agents Chemother. 42 (1998) 1702-1705 [PubMed].
  57. Rouch D.A., Byrne M.E., Kong Y.C., Skurray R.A., The aacA-aphD gentamicin and kanamycin resistance determinant of Tn4001 from Staphylococcus aureus: expression and nucleotide sequence analysis, J. Gen. Microbiol. 133 (1987) 3039-3052 [PubMed].
  58. Rouch D.A., Masserotti L.J., Loo L.S.L., Jackson C.A., Skurray R.A., Trimethoprim resistance transposon Tn4003 from Staphylococcus aureus encodes genes for a dihydrofolate reductase and thymidylate synthetase flanked by three copies of IS257, Mol. Microbiol. 3 (1989) 161-175 [PubMed].
  59. Salyers A.A., Whitt D.D., Bacterial pathogenesis: a molecular approach, ASM Press, Washington D.C., USA, 1994.
  60. Salyers A.A., Shoemaker N.B., Stevens A.M., Li L.-Y., Conjugative transposons: an unusual and diverse set of integrated gene transfer elements, Microbiol. Rev. 59 (1995) 579-590 [PubMed].
  61. Schwarz S., Noble W.C., Aspects of bacterial resistance to antimicrobial agents used in veterinary dermatological practice, Vet. Dermatol. 10 (1999) 163-176.
  62. Schwarz S., Werckenthin C., Kehrenberg C., Identification of a plasmid-borne chloramphenicol-florfenicol resistance gene from Staphylococcus sciuri, Antimicrob. Agents Chemother. 44 (2000) 2530-2533 [CrossRef] [PubMed].
  63. Schwarz S., Kehrenberg C., Walsh T.R., Use of antimicrobial agents in veterinary medicine and food animal production, Int. J. Antimicrob. Agents 17 (2001) 431-437 [PubMed].
  64. Shaw K.J., Rather P.N., Hare S.R., Miller G.H., Molecular genetics of aminoglycoside resistance genes and familial relationships of the aminoglycoside-modifying enzymes, Microbiol. Rev. 57 (1993) 138-163 [PubMed].
  65. Shaw W.V., Chloramphenicol acetyltransferase: enzymology and molecular biology, Crit. Rev. Biochem. 14 (1983) 1-46.
  66. Sköld O., Resistance to trimethoprim and sulfonamides, Vet. Res. 32 (2001).
  67. Speer B.S., Shoemaker N.B., Salyers A.A., Bacterial resistance to tetracyclines: mechanisms, transfer, and clinical significance, Clin. Microbiol. Rev. 5 (1992) 387-399 [PubMed].
  68. Stanisich V.A., Identification and analysis of plasmids at the genetic level, in: Grinsted J., Bennett P.M. (Eds.), Plasmid Technology, Academic Press, London, 1988, pp. 11-48.
  69. Taylor D.E., Chau A., Tetracycline resistance mediated by ribosomal protection, Antimicrob. Agents Chemother. 40 (1996) 1-5 [PubMed].
  70. Then R.L., Mechanisms of resistance to trimethoprim, the sulfonamides, and trimethoprim-sulfamethoxazole, Rev. Infect. Dis. 4 (1982) 261-269 [PubMed].
  71. Theuretzbacher U., $\beta$-Lactamases and $\beta$-lactamase inhibitors, Chemother. J. 7 (1998) 136-142.
  72. Ungemach F.R., Figures on quantities of antibacterials used for different purposes in the EU countries and interpretation, Acta Vet. Scand. Suppl. 93 (2000) 89-97 [PubMed].
  73. Webber M., Piddock L.J.V., Quinolone resistance in Escherichia coli, Vet. Res. 32 (2001) 275-284 [CrossRef] [PubMed] [EDP Sciences].
  74. Weisblum B., Erythromycin resistance by ribosome modification, Antimicrob. Agents Chemother. 39 (1995) 577-585 [PubMed].
  75. Weisblum B., Insights into erythromycin action from studies of its activity as inducer of resistance, Antimicrob. Agents Chemother. 39 (1995) 797-805 [PubMed].
  76. Werckenthin C., Schwarz S., Westh H., Structural alterations in the translational attenuators of constitutively expressed erm(C) genes, Antimicrob. Agents Chemother 43 (1999) 1681-1685 [PubMed].
  77. White D.G., Hudson C., Maurer J.J., Ayers S., Zhao S., Lee M.D., Bolton L., Foley T., Sherwood J., Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea, J. Clin. Microbiol. 38 (2000) 4593-4598 [PubMed].
  78. Witte W., Klare I., Antibiotikaresistenz bei bakteriellen Infektionserregern: Mikrobiologisch-epidemiologische Aspekte, Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz 42 (1999) 8-16 [CrossRef].
  79. Woodward K.N., Maximum residue limits - The impact of the UK and the EC legislation. Recent advances in animal nutrition, 1993, pp. 165-172.
  80. Wright G.D., Aminoglycoside-modifying enzymes, Curr. Opin. Microbiol. 2 (1999) 499-503 [CrossRef] [PubMed].