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Table I.
The emergence of specific mutations in the genome of CPV that became widespread during the evolution of the virus in dogs.
| Mutation(s) that have become widespread | Mutant virus name (if any) | Year of first recognition (approximate in some cases) | Relative prevalence |
|---|---|---|---|
| VP2 residues | FPV to CPV | Associated with the host range switch from cats to dogs. Result in altered binding to the canine transferrin receptor. | |
| 80 Arg to Lys | |||
| 93 Lys to Asn | |||
| 103 Val to Ala | |||
| 323 Asp to Asn | |||
| 564 Asn to Ser | |||
| 568 Ala to Gly | |||
| VP2 residues | CPV-2a | 1979 | 100% by ~ 1980 |
| 87 Met to Leu | |||
| 101 Ile to Thr | |||
| 300 Ala to Gly | |||
| 305 Asp to Tyr | |||
| VP2 residue 426 Asn to Asp | CPV-2b | 1984 | 30–80% between 1984 and 2005 |
| VP2 residue 297 Ser to Ala | 1990 | Increasing to > 90% by 2000 | |
| VP2 residue 426 Asp to Glu | CPV-2c | 2001 | Increasing after 2001, becoming globally distributed; no estimate available |
| VP2 residue 440, Thr to Ala | ~ 2005 | Found in several countries around world, no estimate available |