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Table II.
Canonical pathways significantly over-represented by E. bovis-regulated genes in infected bovine endothelial host cells (p ≤ 0.05).
| Canonical Pathwaya | p.i. | Molecules |
|---|---|---|
| Aryl Hydrocarbon Receptor Signaling | 4 h | FOS, CYP1A1 |
| 8 d | NR2F1, MYC, FOS, CCNE1, CCND2, TGFB2 | |
| 14 d | GSTM1, MGST1, CCNE2, GSTP1, IL6, MYC, NR2F1, FOS, CCNE1, JUN, CCND3, CCND2, SP1, CDKN1A, ALDH1A2, TGFB2, HSP90AA1, ALDH18A1, HSPB1, GSTK1 |
|
| HMGB1 Signaling | 4 d | FOS, SERPINE1 |
| 8 d | IL8, FOS, VCAM1, ICAM1, SERPINE1, PLAT | |
| 14 d | KAT2B, FOS, JUN, MAPK14, SP1, CDC42, RBBP7, MRAS, IFNGR2, PIK3R2, PLAT |
|
| HGF Signaling | 14 d | MAP3K11, CDC42, PLCG1, IL6, FOS, JUN, GAB1, CDKN1A, MRAS, PRKCH, MAP3K8, PIK3R2, ELK3, MAP3K3 |
| IGF-1 Signaling | 4 d | FOS, IGFBP5, NEDD4 |
| 14 d | FOS, YWHAG, JUN, NOV, YWHAH, MRAS, RPS6KB2, IGFBP5, PRKCH, PIK3R2, CYR61, GRB10 |
|
| ERK5 Signaling | 4 h | FOS |
| 14 d | MYC, FOS, YWHAG, YWHAH, GAB1, MRAS, RPS6KB2, MAP3K8, MEF2C, RPS6KA5, MAP3K3 |
|
| NRF2-mediated Oxidative Stress Response | 14 d | AKR7A2, GSTM1, GSTP1, USP14, MGST1, DNAJC3, DNAJA1, FOS, MAPK14, SOD2, JUN, SCARB1, STIP1, MRAS, UBE2K, DNAJC1, PRKCH, PIK3R2, DNAJB6, GSTK1 |
| Protein Ubiquitination Pathway | 14 d | PSMB9, UCHL3, USP14, PSMB5, PSMD7, PSMC4, USP54, THOP1, UBE2S, HSPA5, USP2, PSMB6, TAP1, PSMD8, UBE2F, UCHL1, HSPA8, USP53, PSMB2, HSP90AA1, PSMD14, USP40, UBE2E1 |
| Acute Phase Response | 8 d | SOCS1, FOS, SOD2, C1S, NOLC1, CFB, SERPINE1 |
| Leukocyte Extravasation Signaling | 8 d | TIMP4, VCAM1, ICAM1, EZR, TIMP2 |
| 14 d | TIMP3, CDC42, CXCR4, MMP16, PLCG1, RAPGEF3, WIPF1, TIMP4, MAPK14, CDH5, CLDN1, EZR, CYBA, CLDN16, CD44, MMP11, PRKCH, PIK3R2, VCL, TIMP2 |
|
| IL-8 Signaling | 8 d | IL8, VCAM1, ICAM1, CCND2, CXCL1, VEGFC |
| Coagulation System | 4 d | PLAUR, PLAU, SERPINE1 |
| 8 d | PLAUR, PLAU, SERPINE1, PLAT | |
| Cell Cycle: G1/S Checkpoint Regulation | 8 d | MYC, CCNE1, CCND2, TGFB2 |
| 14 d | MYC, CCNE2, CCNE1, CCND3, HDAC3, CCND2, CDKN1A, TGFB2 |
|
| Cell Cycle: G2/M DNA Damage Regulation | 8 d | TOP2A, CCNB2, BRCA1 |
| 14 d | KAT2B, GADD45A, PTPMT1, CDKN1A, TOP2A, CCNB2 |