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Table I.
Treatment with FMDV-specific rS. cho or a mixture of rS. cho and rAd5 inhibits FMDV HKN/2002 infection in guinea pigsa.
| Group | Treatment (CFU or PFU)b | No. protected/no. challenged for dpc |
pc | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 1 | 2 | 3 | 4 | 5 | 6 | 14 | |||
| Saline | 3/5 | 0/5 | – | – | – | – | – | AC | |
| pLacZ/S. cho | 109 | 4/5 | 1/5 | 0/5 | – | – | – | – | 0.308 |
| p3D-NT56/S. cho | 109 | 5/5 | 5/5 | 4/5 | – | – | – | – | 0.00313 |
| p3D-NT19/S. cho | 109 | 5/5 | 2/5 | – | – | – | – | – | 0.0571 |
| S. cho | 109 | 1/5 | 1/5 | 0/5 | – | – | – | – | 0.787 |
| pLacZ/S. cho | 108 | 4/5 | 0/5 | – | – | – | – | – | 0.513 |
| p3D-NT56/S. cho | 108 | 5/5 | 3/5 | 2/5 | 2/5 | 1/5 | – | – | 0.029 |
| pLacZ/S. cho | 1010 | 5/5 | 1/5 | 1/5 | 0/5 | – | – | – | 0.0951 |
| p3D-NT56/S. cho | 1010 | 5/5 | 4/5 | 2/5 | 2/5 | 1/5 | – | – | 0.0116 |
| Ad5-LacZ+pLacZ/S. cho | 106 + 109 | 2/5 | 0/5 | – | – | – | – | – | 0.549 |
| Ad5-POL+p3D-NT56/S. cho | 106 + 109 | 5/5 | 3/5 | – | – | – | – | – | 0.029 |
| Ad5-LacZ | 106 | 3/5 | 1/5 | 1/5 | 0/5 | – | – | – | 0.602 |
| Ad5-POL | 106 | 5/5 | 5/5 | 3/5 | 2/5 | – | – | – | 0.00313 |