Open Access

Table I.

Treatment with FMDV-specific rS. cho or a mixture of rS. cho and rAd5 inhibits FMDV HKN/2002 infection in guinea pigsa.

Group Treatment (CFU or PFU)b No. protected/no. challenged for dpc
pc
1 2 3 4 5 6 14
Saline 3/5 0/5 AC
pLacZ/S. cho 109 4/5 1/5 0/5 0.308
p3D-NT56/S. cho 109 5/5 5/5 4/5 0.00313
p3D-NT19/S. cho 109 5/5 2/5 0.0571
S. cho 109 1/5 1/5 0/5 0.787
pLacZ/S. cho 108 4/5 0/5 0.513
p3D-NT56/S. cho 108 5/5 3/5 2/5 2/5 1/5 0.029
pLacZ/S. cho 1010 5/5 1/5 1/5 0/5 0.0951
p3D-NT56/S. cho 1010 5/5 4/5 2/5 2/5 1/5 0.0116
Ad5-LacZ+pLacZ/S. cho 106 + 109 2/5 0/5 0.549
Ad5-POL+p3D-NT56/S. cho 106 + 109 5/5 3/5 0.029
Ad5-LacZ 106 3/5 1/5 1/5 0/5 0.602
Ad5-POL 106 5/5 5/5 3/5 2/5 0.00313
a

–: Score is the same as the day before.

b

CFU for rS. cho and PFU for rAd5.

c

Statistical analysis by the log rank test.

Days post-challenge (dpc) and AC: as controls.