State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology | Veterinary Research, a journal on Animal Infection

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Table II.

Currently observed frequency range reported for variant haplotypes associated with partial resistance to scrapie.

	Italy	France	USA	Japan	China
M142	0.0–28.2^*	3.9–8.7	0.0–43.2	4.6	0.0
	(5/8)^**	(2/2)	(4/10)	(1/1)
R143	0.0–5.4	0.0	0.0–10.9	3.0	14.3–57.1
	(4/8)		(4/10)	(1/1)	(5/5)
S146	0.0	0.0	0.0–35.2	1.7	0.0–57.4 (1/5)
D146			(7/10)	(1/1)
H154	0.0–11.3 (6/8)	0.5–5.4	0.0–1.8	0.0	7.4–46.6
		(2/2)	(1/10)		(5/5)
Q211	0.0–13.7 (4/8)	7.1–18.5	0.0–9.7 (5/10)	12.7	0.0
		(2/2)		(1/1)
K222	1.3–17.2 (8/8)	4.9–7.5	0.0–5.4 (2/10)	0.0	0.0–21.7 (1/5)
		(2/2)

Minimum and maximum percentage frequencies of the haplotype relative to all haplotypes observed in the respective study.

^**

Number of breeds in which the haplotype has been found out of the total breeds included in the study.