State-of-the-art review of goat TSE in the European Union, with special emphasis on PRNP genetics and epidemiology

Gabriele Vaccari; Cynthia H. Panagiotidis; Cristina Acin; Simone Peletto; Francis Barillet; Pierluigi Acutis; Alex Bossers; Jan Langeveld; Lucien Van Keulen; Theodoros Sklaviadis; Juan J. Badiola; Olivier Andreéoletti; Martin H. Groschup; Umberto Agrimi; James Foster; Wilfred Goldmann

doi:doi:10.1051/vetres/2009031

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Volume 40 / No 5 (September-October 2009)

Vet. Res., 40 5 (2009) 48

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Table I.

Known caprine PRNP gene polymorphisms^a.

Polymorphism	EU countries reported from	Non-EU countries reported from	First reference
W18R	ES		t.p.
V21A	GR		[10]
L23P	GR		[10]
G37V	IT		[4]
P42P	UK, IT, FR, GR	US, CN, JP, PK	[33]
G49S	GR		[10]
Q101R	UK		t.p.
Q101Q	NL		t.p.
W102G	UK	CN, JP	[34]
K107K	GR		[10]
T110P	IT		[4]
V125V		CN	[76]
G127S	IT, UK, ES, FR	US, CN, JP	[75]
L133Q	IT		[1]
M137I	IT		[1]
S138S	UK, IT, FR, CY, GR	US, CN, JP, PK	[33]
I142M	UK, FR, ES	US, JP	[33]
I142T	IT		[2]
I142I	NL		t.p.
H143R	UK, IT, GR, NL	US, CN, JP	[33]
N146D	CY		[54]
N146S	CY, UK	US, CN, JP	[75] [45]
R151H	CY		[54]
R154H	GR, IT, ES, CY, FR	US, CN	[10]
P168Q	IT, GR, CY		[10]
V179V	CY		[54]
D181D	CY		[54]
T194P	IT		[2]
F201F	ES		t.p.
T202T	IT		[1]
K207K	GR		[10]
R211Q	UK, FR, ES	US, CN, JP	[74]
R211G		CN	[76]
I218L		CN	[75]
T219I	ES	CN	[76]
T219T	IT		[66]
Q220H	FR, CY, GR		[10]
Q222K	IT, FR, UK, ES	US, CN	[4]
Q222Q	NL		t.p.
G232W	ES		t.p.
G232G	IT		[66]
S240P	IT, FR, UK, GR, ES, CY, NL	US, CN, JP, PK	[33]

^a

Coding polymorphisms in regular print, silent mutations in italics. The designation t.p. indicates polymorphisms communicated for first time in this paper.