Rapid and widely disseminated acute phase protein response after experimental bacterial infection of pigs

Kerstin Skovgaard; Shila Mortensen; Mette Boye; Karin T. Poulsen; Fiona M. Campbell; P. David Eckersall; Peter M.H. Heegaard

doi:doi:10.1051/vetres/2009006

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Volume 40 / No 3 (May-June 2009)

Vet. Res., 40 3 (2009) 23

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Table II.

Extrahepatic and hepatic expression of APP and IL-6 ± standard error of the mean. The mean value of the 10 infected animals is shown relative to the 5 control animals as described in Materials and methods.

Gene	Tissue
	Liver	Leukocytes	Spleen	Lymph	Tonsil
AGP	0.46 ± 0.04**	E (3/5 10/10)^a	E (1/5 5/10)	E (2/5 2/10)	Not expressed
ALB	0.16 ± 0.02***	E (5/5 9/10)	E (5/5 1/10)	E (1/5 1/10)	0.75 ± 0.08
APOA1	0.53 ± 0.08*	0.53 ± 0.23	0.74 ± 0.09*	2.03 ± 1.26	1.16 ± 0.46
CRP	2.10 ± 0.41*	4.88 ± 1.72**	E (3/5 5/10)	3.70 ± 0.81***	E (2/5 5/10)
FIB	3.02 ± 0.21***	Not expressed	4.12 ± 1.11***	E (4/5 9/10)	Not expressed
Hp	1.92 ± 0.23**	23.23 ± 5.24***	21.55 ± 4.93***	3.42 ± 0.81**	0.94 ± 0.41
PigMAP	7.47 ± 0.48***	E (5/5 10/10)^b	4.36 ± 0.62***	5.43 ± 1.72*	2.27 ± 0.55**
SAA2	68.19 ± 12.90***	95.66 ± 21.30***	24.52 ± 9.70***	668 ± 160**	2.11 ± 0.28*
TF	0.17 ± 0.02***	0.45 ± 0.12	0.37 ± 0.05**	1.30 ± 0.26	1.32 ± 0.27
TTR	0.04 ± 0.0***	E (1/5 1/10)	0.39 ± 0.06	0.83 ± 0.18	E (4/5 6/10)
IL-6	11.16 ± 8.30*	7.46 ± 3.31*	14.08 ± 7.49***	167 ± 130**	4.37 ± 1.81*

^a

Expressed in 3 out of 5 control animals and 10 out of 10 infected animals.

^b

Due to very low expression in a few control animals we were not able to quantify PigMAP in leukocytes.

* p < 0.05, ** p < 0.01, *** p < 0.001 Wilcoxon rank sum test.