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Vet. Res.
Volume 32, Number 3-4, May-August 2001
Mechanisms of resistance to antibiotics in animal and zoonotic pathogens
Page(s) 311 - 321
How to cite this article Vet. Res. (2001) 311-321
DOI: 10.1051/vetres:2001127

Vet. Res. 32 (2001) 311-321

Antimicrobial resistance of thermophilic Campylobacter

Frank M. Aarestrupa and Jørgen Engbergb

a  Danish Veterinary Laboratory, 27 Bülowsvej, DK-1790 Copenhagen V, Denmark
b  Statens Serum Institiut, Artillerivej 5, DK-2300 Copenhagen S, Denmark

(Received 8 January 2001; accepted 12 March 2001)

Campylobacter has become the leading cause of zoonotic enteric infections in developed and developing countries world-wide. Antimicrobial resistance has emerged among Campylobacter mainly as a consequence of the use of antimicrobial agents in food animal production. Resistance to drugs of choice for the treatment of infections, macrolides and fluoroquinolones has emerged as a clinical problem and interventions to reduce this are recommended. Resistance to fluoroquinolones and macrolides is mediated by chromosomal mutations. Resistance to other relevant antimicrobial agents, mediated by acquired resistance genes, has not become widespread so far. However, resistance genes originating from both Gram-positive and Gram-negative bacterial species have been found, showing the potential for acquired resistance to emerge in Campylobacter.

Résistance aux antimicrobiens chez Campylobacter thermophile. Campylobacter est devenu la cause principale de zoonoses entériques infectieuses dans les pays développés et en voie de développement à travers le monde. La résistance aux antibiotiques a émergé chez Campylobacter, principalement à cause de l'utilisation d'antibiotiques chez les animaux entrant dans la chaîne alimentaire. La résistance aux antibiotiques principalement utilisés dans le traitement des infections, les macrolides et les fluoroquinolones, a émergé en tant que problème clinique, et les interventions visant à réduire cette résistance sont recommandées. La résistance aux fluoroquinolones et aux macrolides est due à des mutations chromosomiques. La résistance aux autres antibiotiques utilisables, qui est due à l'acquisition de gènes de résistance, ne s'est jusqu'à maintenant pas propagée. Cependant, le fait qu'il ait été trouvé des gènes de résistance ayant pour origine des espèces bactériennes à Gram-positif et à Gram-négatif, montre la possibilité d'émergence de résistance acquise chez Campylobacter.

Key words: Campylobacter / resistance / susceptibility testing / trends / gene

Mots clés : Campylobacter / résistance / test de sensibilité / tendance / gène

Correspondence and reprints: Frank M. Aarestrup Tel.: (45) 35 30 01 00; fax: (45) 35 30 01 20;

© INRA, EDP Sciences 2001

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