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Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field
Sara Canoyra, Alba Marín-Moreno, Juan Carlos Espinosa, Natalia Fernández-Borges, Enric Vidal, Leonor Orge, Sylvie L. Benestad, Olivier Andréoletti and Juan María Torres Proceedings of the National Academy of Sciences 122(29) (2025) https://doi.org/10.1073/pnas.2501104122
Co-presence of classical scrapie but not classical Bovine Spongiform Encephalopathy in transmissions from Dutch sheep with atypical scrapie
Lucien J. van Keulen, Corry H. Dolstra, Ruth Bossers-de Vries and Alex Bossers Journal of General Virology 106(12) (2025) https://doi.org/10.1099/jgv.0.002202
Silent Propagation of Classical Scrapie Prions in Homozygous K222 Transgenic Mice
Natalia Fernández-Borges, Alba Marín-Moreno, Juan Carlos Espinosa, Sara Canoyra, Olivier Andréoletti and Juan María Torres Emerging Infectious Diseases 31(12) (2025) https://doi.org/10.3201/eid3112.250302
Conservation of strain properties of bank vole-adapted chronic wasting disease in the absence of glycosylation and membrane anchoring
Enric Vidal, Hasier Eraña, Jorge M. Charco, Nuria L. Lorenzo, Samanta Giler, Montserrat Ordóñez, Eva Fernández-Muñoz, Maitena San Juan Ansoleaga, Glenn C. Telling, Manuel A. Sánchez-Martín, Mariví Geijo, Jesús R. Requena and Joaquín Castilla Neurobiology of Disease 106894 (2025) https://doi.org/10.1016/j.nbd.2025.106894
Strain-Dependent Susceptibility to Prion Infection Encoded by Arg171 and Lys176 Sheep Prion Protein Polymorphic Variants
Juan Carlos Espinosa, Natalia Fernández-Borges, Alba Marín-Moreno, Sara Canoyra, Patricia Aguilar-Calvo, Belén Pintado, Eva Pericuesta, Sylvie L Benestad, Romolo Nonno, Olivier Andréoletti and Juan María Torres The Journal of Infectious Diseases 232(1) e89 (2025) https://doi.org/10.1093/infdis/jiaf170
Retention of prions in the polychaete Hediste diversicolor and black soldier fly, Hermetia illucens, larvae after short-term experimental immersion and feeding with brain homogenate from scrapie infected sheep
Diagnosis in Scrapie: Conventional Methods and New Biomarkers
Diego Sola, Marina Betancor, Paula A. Marco Lorente, Sonia Pérez Lázaro, Tomás Barrio, Eloisa Sevilla, Belén Marín, Bernardino Moreno, Marta Monzón, Cristina Acín, Rosa Bolea, Juan J. Badiola and Alicia Otero Pathogens 12(12) 1399 (2023) https://doi.org/10.3390/pathogens12121399
Experimental transmission of ovine atypical scrapie to cattle
Timm Konold, John Spiropoulos, Janet Hills, Hasina Abdul, Saira Cawthraw, Laura Phelan, Amy McKenna, Lauren Read, Sara Canoyra, Alba Marín-Moreno and Juan María Torres Veterinary Research 54(1) (2023) https://doi.org/10.1186/s13567-023-01224-3
XV International Scientific Conference “INTERAGROMASH 2022”
Nadezhda Taranukha, Natalia Fedota, Yuliya Dyachenko, Eduard Gorchakov and Bagama Bagamaev Lecture Notes in Networks and Systems, XV International Scientific Conference “INTERAGROMASH 2022” 574 594 (2023) https://doi.org/10.1007/978-3-031-21432-5_62
A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants
Laura Pirisinu, Michele Angelo Di Bari, Claudia D’Agostino, et al. PLOS Pathogens 18(6) e1010646 (2022) https://doi.org/10.1371/journal.ppat.1010646
Samia Hannaoui, Irina Zemlyankina, Sheng Chun Chang, Maria Immaculata Arifin, Vincent Béringue, Debbie McKenzie, Hermann M. Schatzl and Sabine Gilch (2022) https://doi.org/10.1101/2022.04.19.488833
The Translational Benefits of Sheep as Large Animal Models of Human Neurological Disorders
Gene-Edited Cell Models to Study Chronic Wasting Disease
Simrika Thapa, Cristobal Marrero Winkens, Waqas Tahir, Maria I. Arifin, Sabine Gilch and Hermann M. Schatzl Viruses 14(3) 609 (2022) https://doi.org/10.3390/v14030609
PrPres in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay
Leonor Orge, Carla Lima, Carla Machado, Paula Tavares, Paula Mendonça, Paulo Carvalho, João Silva, Maria de Lurdes Pinto, Estela Bastos, Jorge Cláudio Pereira, Nuno Gonçalves-Anjo, Adelina Gama, Alexandra Esteves, Anabela Alves, Ana Cristina Matos, Fernanda Seixas, Filipe Silva, Isabel Pires, Luis Figueira, Madalena Vieira-Pinto, Roberto Sargo and Maria dos Anjos Pires Biomolecules 11(3) 466 (2021) https://doi.org/10.3390/biom11030466
Research Relevant Background Lesions and Conditions: Ferrets, Dogs, Swine, Sheep, and Goats
Cervid Prion Protein Polymorphisms: Role in Chronic Wasting Disease Pathogenesis
Maria Immaculata Arifin, Samia Hannaoui, Sheng Chun Chang, Simrika Thapa, Hermann M. Schatzl and Sabine Gilch International Journal of Molecular Sciences 22(5) 2271 (2021) https://doi.org/10.3390/ijms22052271
Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases
Zoe J. Lambert, Justin J. Greenlee, Eric D. Cassmann and M. Heather West Greenlee Viruses 13(12) 2453 (2021) https://doi.org/10.3390/v13122453
Circulation of Nor98 Atypical Scrapie in Portuguese Sheep Confirmed by Transmission of Isolates into Transgenic Ovine ARQ-PrP Mice
Mafalda Casanova, Carla Machado, Paula Tavares, João Silva, Christine Fast, Anne Balkema-Buschmann, Martin H. Groschup and Leonor Orge International Journal of Molecular Sciences 22(19) 10441 (2021) https://doi.org/10.3390/ijms221910441
Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases
Cristina Acín, Rosa Bolea, Marta Monzón, Eva Monleón, Bernardino Moreno, Hicham Filali, Belén Marín, Diego Sola, Marina Betancor, Isabel M. Guijarro, Mirta García, Antonia Vargas and Juan José Badiola Animals 11(3) 691 (2021) https://doi.org/10.3390/ani11030691
Scientific report on the analysis of the 2‐year compulsory intensified monitoring of atypical scrapie
Mark Arnold, Giuseppe Ru, Marion Simmons, Alberto Vidal‐Diez, Angel Ortiz‐Pelaez and Pietro Stella EFSA Journal 19(7) (2021) https://doi.org/10.2903/j.efsa.2021.6686
Scrapie at Abattoir: Monitoring, Control, and Differential Diagnosis of Wasting Conditions during Meat Inspection
Alexandra Esteves, Madalena Vieira-Pinto, Hélder Quintas, Leonor Orge, Adelina Gama, Anabela Alves, Fernanda Seixas, Isabel Pires, Maria de Lurdes Pinto, Ana Paula Mendonça, Carla Lima, Carla Neves Machado, João Carlos Silva, Paula Tavares, Filipe Silva, Estela Bastos, Jorge Pereira, Nuno Gonçalves-Anjo, Paulo Carvalho, Roberto Sargo, Ana Matos, Luís Figueira and Maria dos Anjos Pires Animals 11(11) 3028 (2021) https://doi.org/10.3390/ani11113028
Classical scrapie in small ruminants is caused by at least four different prion strains
Transmissible spongiform encephalopathy in goats: is PrP rapid test sensitivity affected by genotype?
Marion M. Simmons, Leigh Thorne, Angel Ortiz-Pelaez, John Spiropoulos, Soteria Georgiadou, Penelope Papasavva-Stylianou, Olivier Andreoletti, Stephen A.C. Hawkins, Daniela Meloni and Claire Cassar Journal of Veterinary Diagnostic Investigation 32(1) 87 (2020) https://doi.org/10.1177/1040638719896327
Dogs are resistant to prion infection, due to the presence of aspartic or glutamic acid at position 163 of their prion protein
Enric Vidal, Natalia Fernández‐Borges, Hasier Eraña, Beatriz Parra, Belén Pintado, Manuel A. Sánchez‐Martín, Jorge M. Charco, Montserrat Ordóñez, Miguel A. Pérez‐Castro, Martí Pumarola, Candace K. Mathiason, Tomás Mayoral and Joaquín Castilla The FASEB Journal 34(3) 3969 (2020) https://doi.org/10.1096/fj.201902646R
The Scrapie Prevalence in a Goat Herd Is Underestimated by Using a Rapid Diagnostic Test
Genotyping of prion protein in black merino sheep from the Iberian Peninsula
Pedro Martin Palomino, Laura Gomez Calle, Joao Serejo Proença, Elena Ruiz Maestre and José Luis Fernández-Garcia Small Ruminant Research 173 36 (2019) https://doi.org/10.1016/j.smallrumres.2019.02.010
Enric Vidal, Natalia Fernández-Borges, Hasier Eraña, Beatriz Parra, Belén Pintado, Manuel A Sánchez-Martín, Jorge M Charco, Montserrat Ordoñez, Miguel A Pérez-Castro, Martí Pumarola, Candace K. Mathiason, Tomás Mayoral and Joaquín Castilla (2019) https://doi.org/10.1101/800698
Review: Update on Classical and Atypical Scrapie in Sheep and Goats
The emergence of classical BSE from atypical/Nor98 scrapie
Alvina Huor, Juan Carlos Espinosa, Enric Vidal, et al. Proceedings of the National Academy of Sciences 116(52) 26853 (2019) https://doi.org/10.1073/pnas.1915737116
Raccoons accumulate PrPSc after intracranial inoculation of the agents of chronic wasting disease or transmissible mink encephalopathy but not atypical scrapie
S. Jo Moore, Jodi D. Smith, Jürgen A. Richt and Justin J. Greenlee Journal of Veterinary Diagnostic Investigation 31(2) 200 (2019) https://doi.org/10.1177/1040638718825290
Using an epidemiological framework and bovine spongiform encephalopathy investigation questionnaire to investigate suspect bovine spongiform encephalopathy cases: an example from a bovine spongiform encephalopathy case in Ireland in 2015
Jarlath T O'Connor, Justin P Byrne, Simon J More, Martin Blake, Guy McGrath, Jamie A Tratalos, Maire C McElroy, Paul Kiernan, Mary J Canty, Chris O'Brien‐Lynch and John M Griffin Veterinary Record 182(6) 168 (2018) https://doi.org/10.1136/vr.104148
Animal TSEs and public health: What remains of past lessons?
Genetic diversity of the prion protein gene (PRNP) coding sequence in Czech sheep and evaluation of the national breeding programme for resistance to scrapie in the Czech Republic
Prion protein gene polymorphisms in Turkish native goat breeds
HASAN MEYDAN, ERKAN PEHLİVAN, MUSTAFA MUHIP ÖZKAN, MEHMET ALI YILDIZ and WILFRED GOLDMANN Journal of Genetics 96(2) 299 (2017) https://doi.org/10.1007/s12041-017-0763-1
Identification of the first case of atypical scrapie in Japan
Morikazu IMAMURA, Kohtaro MIYAZAWA, Yoshifumi IWAMARU, et al. Journal of Veterinary Medical Science 78(12) 1915 (2016) https://doi.org/10.1292/jvms.16-0379
Transmissibility of Gerstmann–Sträussler–Scheinker syndrome in rodent models: New insights into the molecular underpinnings of prion infectivity
Report of outbreaks of classical scrapie in Dorper sheep and associated prion protein gene polymorphisms in affected flocks
Caroline Pinto de Andrade, Eduardo Conceição de Oliveira, Juliano Souza Leal, et al. Tropical Animal Health and Production 47(6) 1203 (2015) https://doi.org/10.1007/s11250-015-0849-9
Does the Presence of Scrapie Affect the Ability of Current Statutory Discriminatory Tests To Detect the Presence of Bovine Spongiform Encephalopathy?