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Bifunctional carbazole derivatives for simultaneous therapy and fluorescence imaging in prion disease murine cell models
Matteo Staderini, Silvia Vanni, Arianna Colini Baldeschi, Gabriele Giachin, Marco Zattoni, Luigi Celauro, Chiara Ferracin, Edoardo Bistaffa, Fabio Moda, Daniel I. Pérez, Ana Martínez, M. Antonia Martín, Olmo Martín-Cámara, Ángel Cores, Giulia Bianchini, Robert Kammerer, J. Carlos Menéndez, Giuseppe Legname and Maria Laura Bolognesi European Journal of Medicinal Chemistry 245 114923 (2023) https://doi.org/10.1016/j.ejmech.2022.114923
Tackling prion diseases: a review of the patent landscape
Cellular models for discovering prion disease therapeutics: Progress and challenges
Saffire H. Krance, Russell Luke, Marc Shenouda, et al. Journal of Neurochemistry 153(2) 150 (2020) https://doi.org/10.1111/jnc.14956
Merve Avar, Daniel Heinzer, Nicolas Steinke, Berre Doğançay, Rita Moos, Severine Lugan, Claudia Cosenza, Simone Hornemann, Olivier Andréoletti and Adriano Aguzzi (2020) https://doi.org/10.1101/2020.04.01.019786
BMD42-2910, a Novel Benzoxazole Derivative, Shows a Potent Anti-prion Activity and Prolongs the Mean Survival in an Animal Model of Prion Disease
A New Cell Model for Investigating Prion Strain Selection and Adaptation
Alexandra Philiastides, Juan Manuel Ribes, Daniel Chun-Mun Yip, Christian Schmidt, Iryna Benilova and Peter-Christian Klöhn Viruses 11(10) 888 (2019) https://doi.org/10.3390/v11100888
Engineering a murine cell line for the stable propagation of hamster prions
Pascal Leblanc, Zaira E. Arellano-Anaya, Emilien Bernard, et al. Methods in Molecular Biology, Exosomes and Microvesicles 1545 153 (2017) https://doi.org/10.1007/978-1-4939-6728-5_11
A stretch of residues within the protease-resistant core is not necessary for prion structure and infectivity
Synthesis and Evaluation of 1‐Amino‐6‐halo‐β‐carbolines as Antimalarial and Antiprion Agents
Mark J. Thompson, Jennifer C. Louth, Susan M. Little, Matthew P. Jackson, Yohan Boursereau, Beining Chen and Iain Coldham ChemMedChem 7(4) 578 (2012) https://doi.org/10.1002/cmdc.201200002
Cytochalasin D enhances the accumulation of a protease‐resistant form of prion protein in ScN2a cells: involvement of PI3 kinase/Akt signalling pathway
Takato Takenouchi, Yoshifumi Iwamaru, Morikazu Imamura, et al. Cell Biology International 36(12) 1223 (2012) https://doi.org/10.1042/CBI20120329
Prion inhibition with multivalent PrPSc binding compounds
Structure–Activity Relationship Refinement and Further Assessment of Indole‐3‐glyoxylamides as a Lead Series against Prion Disease
Mark J. Thompson, Jennifer C. Louth, Steven Ferrara, Fiona J. Sorrell, Benjamin J. Irving, Edward J. Cochrane, Anthony J. H. M. Meijer and Beining Chen ChemMedChem 6(1) 115 (2011) https://doi.org/10.1002/cmdc.201000383
A Simple, Versatile and Sensitive Cell-Based Assay for Prions from Various Species
Discovery of 6-substituted indole-3-glyoxylamides as lead antiprion agents with enhanced cell line activity, improved microsomal stability and low toxicity
Recovery of Small Infectious PrPres Aggregates from Prion-infected Cultured Cells
Zaira E. Arellano Anaya, Jimmy Savistchenko, Véronique Massonneau, et al. Journal of Biological Chemistry 286(10) 8141 (2011) https://doi.org/10.1074/jbc.M110.165233
Spongiform degeneration induced by neuropathogenic murine coronavirus infection
Improved 2,4‐Diarylthiazole‐Based Antiprion Agents: Switching the Sense of the Amide Group at C5 Leads to an Increase in Potency
Mark J. Thompson, Jennifer C. Louth, Gemma K. Greenwood, Fiona J. Sorrell, Sandra G. Knight, Nathan B. P. Adams and Beining Chen ChemMedChem 5(9) 1476 (2010) https://doi.org/10.1002/cmdc.201000217
Synthesis of Conjugates of 6-Aminophenanthridine and Guanabenz, Two Structurally Unrelated Prion Inhibitors, for the Determination of Their Cellular Targets by Affinity Chromatography
Inducible expression of chimpanzee prion protein (PrP) in murine PrP knock-out cells
Lars Heinig, Daniel A. Mueller, Sanja Ramljak, Edgar Holznagel and Andreas W. Stuke Protein Expression and Purification 70(2) 129 (2010) https://doi.org/10.1016/j.pep.2009.09.015
Conservation of a Glycine-rich Region in the Prion Protein Is Required for Uptake of Prion Infectivity
Christopher F. Harrison, Victoria A. Lawson, Bradley M. Coleman, et al. Journal of Biological Chemistry 285(26) 20213 (2010) https://doi.org/10.1074/jbc.M109.093310
Design, Synthesis, and Structure−Activity Relationship of Indole-3-glyoxylamide Libraries Possessing Highly Potent Activity in a Cell Line Model of Prion Disease
Mark J. Thompson, Vinciane Borsenberger, Jennifer C. Louth, Katie E. Judd and Beining Chen Journal of Medicinal Chemistry 52(23) 7503 (2009) https://doi.org/10.1021/jm900920x
Identification of an Intracellular Site of Prion Conversion