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Innate Immunity Never “NODs” Off: NLRs Regulate the Host Anti‐Viral Immune Response
Mackenzie K. Woolls, Madeline D. Mott, Cassandra S. Poole, Julia A. Gregory, Hannah M. Ivester and Irving Coy Allen Immunological Reviews 330(1) (2025) https://doi.org/10.1111/imr.13429
Brenna C. Remick, Joshua Q. Mao, Andrew G. Manford, Ami D. Gutierrez-Jensen, Allon Wagner, Michael Rape, Grant McFadden, Masmudur M. Rahman, Moritz M. Gaidt and Russell E. Vance (2025) https://doi.org/10.1101/2025.03.04.641538
Genome sequence of the Myxoma virus Borghi vaccine strain
Poxvirus K3 Orthologs Regulate NF-κB-Dependent Inflammatory Responses by Targeting the PKR–eIF2α Axis in Multiple Species
Huibin Yu, Mary Eloise L. Fernandez, Chen Peng, Dewi Megawati, Greg Brennan, Loubna Tazi and Stefan Rothenburg Vaccines 13(8) 800 (2025) https://doi.org/10.3390/vaccines13080800
Breaking Barriers: Animal viruses as oncolytic and immunotherapeutic agents for human cancers
Pathological changes and viral antigen distribution in tissues of Iberian hare (Lepus granatensis) naturally infected with the emerging recombinant myxoma virus (ha‐MYXV)
Irene Agulló‐Ros, Débora Jiménez‐Martín, Leonor Camacho‐Sillero, Christian Gortázar, Lorenzo Capucci, David Cano‐Terriza, Irene Zorrilla, Félix Gómez‐Guillamón, Ignacio García‐Bocanegra and María A. Risalde Veterinary Record 192(1) (2023) https://doi.org/10.1002/vetr.2182
Oncolytic Myxoma virus infects and damages the tegument of the human parasitic flatworm Schistosoma mansoni
Masmudur M. Rahman, Grant McFadden, Gordon Ruthel, De’Broski.R. Herbert, Bruce D. Freedman, Robert M. Greenberg and Swarna Bais Experimental Parasitology 239 108263 (2022) https://doi.org/10.1016/j.exppara.2022.108263
Induction of tumor cell autosis by myxoma virus-infected CAR-T and TCR-T cells to overcome primary and acquired resistance
Ningbo Zheng, Jing Fang, Gang Xue, Ziyu Wang, Xiaoyin Li, Mengshi Zhou, Guangxu Jin, Masmudur M. Rahman, Grant McFadden and Yong Lu Cancer Cell 40(9) 973 (2022) https://doi.org/10.1016/j.ccell.2022.08.001
First cases of myxomatosis in Iberian hares (Lepus granatensis) in Portugal
Carina Luísa Carvalho, Fábio Alexandre Abade dos Santos, Madelena Monteiro, Paulo Carvalho, Paula Mendonça and Margarida Dias Duarte Veterinary Record Case Reports 8(2) (2020) https://doi.org/10.1136/vetreccr-2019-001044
Oncolytic virotherapy in hepato‐bilio‐pancreatic cancer: The key to breaking the log jam?
Yuwei Li, Yinan Shen, Ronghua Zhao, Ismael Samudio, William Jia, Xueli Bai and Tingbo Liang Cancer Medicine 9(9) 2943 (2020) https://doi.org/10.1002/cam4.2949
Coinfections of Novel Polyomavirus, Anelloviruses and a Recombinant Strain of Myxoma Virus-MYXV-Tol Identified in Iberian Hares
Genetic Characterization of a Recombinant Myxoma Virus in the Iberian Hare (Lepus granatensis)
Ana Águeda-Pinto, Ana Lemos de Matos, Mário Abrantes, Simona Kraberger, Maria A. Risalde, Christian Gortázar, Grant McFadden, Arvind Varsani and Pedro J. Esteves Viruses 11(6) 530 (2019) https://doi.org/10.3390/v11060530
Ana Águeda-Pinto, Ana Lemos de Matos, Mário Abrantes, Simona Kraberger, Maria A. Risalde, Christian Gortázar, Grant McFadden, Arvind Varsani and Pedro J. Esteves (2019) https://doi.org/10.1101/624338
Molecular methods in detection and epidemiologic studies of rabbit and hare viruses: a review
Quantitative host resistance drives the evolution of increased virulence in an emerging pathogen
Daisy Elizabeth Gates, John Joseph Valletta, Camille Bonneaud and Mario Recker Journal of Evolutionary Biology 31(11) 1704 (2018) https://doi.org/10.1111/jeb.13366
Effects of myxoma virus and rabbit hemorrhagic disease virus on the physiological condition of wild European rabbits: Is blood biochemistry a useful monitoring tool?
Isabel Pacios-Palma, Simone Santoro, Alejandro Bertó-Moran, Sacramento Moreno and Carlos Rouco Research in Veterinary Science 109 129 (2016) https://doi.org/10.1016/j.rvsc.2016.09.019
An overview of the lagomorph immune system and its genetic diversity
Ana Pinheiro, Fabiana Neves, Ana Lemos de Matos, Joana Abrantes, Wessel van der Loo, Rose Mage and Pedro José Esteves Immunogenetics 68(2) 83 (2016) https://doi.org/10.1007/s00251-015-0868-8
CARD‐ and pyrin‐only proteins regulating inflammasome activation and immunity
Magdalena Matusiak, Nina Van Opdenbosch and Mohamed Lamkanfi Immunological Reviews 265(1) 217 (2015) https://doi.org/10.1111/imr.12282
Genetic characterization of interleukins (IL-1α, IL-1β, IL-2, IL-4, IL-8, IL-10, IL-12A, IL-12B, IL-15 and IL-18) with relevant biological roles in lagomorphs
Fabiana Neves, Joana Abrantes, Tereza Almeida, Ana Lemos de Matos, Paulo P Costa and Pedro J Esteves Innate Immunity 21(8) 787 (2015) https://doi.org/10.1177/1753425915606209
The α2,3-Sialyltransferase Encoded by Myxoma Virus Is a Virulence Factor that Contributes to Immunosuppression
Prevention of EBV lymphoma development by oncolytic myxoma virus in a murine xenograft model of post-transplant lymphoproliferative disease
Manbok Kim, Masmudur M. Rahman, Christopher R. Cogle and Grant McFadden Biochemical and Biophysical Research Communications 462(4) 283 (2015) https://doi.org/10.1016/j.bbrc.2015.03.146
Poxviruses and the evolution of host range and virulence
Pseudogenization of the MCP-2/CCL8 chemokine gene in European rabbit (genus Oryctolagus), but not in species of Cottontail rabbit (Sylvilagus) and Hare (Lepus)
Investigation Of Cytotoxicity Of Negative Control Peptides Versus Bioactive Peptides On Skin Cancer And Normal Cells: A Comparative Study
Nahlah M Almansour, Elena Pirogova, Peter J Coloe, Irena Cosic and Taghrid S Istivan Future Medicinal Chemistry 4(12) 1553 (2012) https://doi.org/10.4155/fmc.12.98
Development and validation of a Myxoma virus real-time polymerase chain reaction assay
Sarah Albini, Brigitte Sigrist, Regula Güttinger, Claude Schelling, Richard K. Hoop and Andrea Vögtlin Journal of Veterinary Diagnostic Investigation 24(1) 135 (2012) https://doi.org/10.1177/1040638711425946
Production of Myxoma Virus Gateway Entry and Expression Libraries and Validation of Viral Protein Expression
Sherin E. Smallwood, Masmudur M. Rahman, Steven J. Werden, Maria Fernanda Martino and Grant McFadden Current Protocols in Microbiology 21(1) (2011) https://doi.org/10.1002/9780471729259.mc14a02s21
Myxoma Virus Lacking the Pyrin-Like Protein M013 Is Sensed in Human Myeloid Cells by both NLRP3 and Multiple Toll-Like Receptors, Which Independently Activate the Inflammasome and NF-κB Innate Response Pathways
Infection of Nonhost Species Dendritic Cells
In Vitro
with an Attenuated Myxoma Virus Induces Gene Expression That Predicts Its Efficacy as a Vaccine Vector
The current status and future directions of myxoma virus, a master in immune evasion
Bart Spiesschaert, Grant McFadden, Katleen Hermans, Hans Nauwynck and Gerlinde R Van de Walle Veterinary Research 42(1) 76 (2011) https://doi.org/10.1186/1297-9716-42-76
Detection of myxoma viruses encoding a defective M135R gene from clinical cases of myxomatosis; possible implications for the role of the M135R protein as a virulence factor
Graham J Belsham, Charlotta Polacek, Solvej Ø Breum, Lars E Larsen and Anette Bøtner Virology Journal 7(1) (2010) https://doi.org/10.1186/1743-422X-7-7
Molecular characterization of SG33 and Borghi vaccines used against myxomatosis
Partial sequencing of recent Portuguese myxoma virus field isolates exhibits a high degree of genetic stability
A. Muller, E. Silva, J. Abrantes, P.J. Esteves, P.G. Ferreira, J.C. Carvalheira, N. Nowotny and G. Thompson Veterinary Microbiology 140(1-2) 161 (2010) https://doi.org/10.1016/j.vetmic.2009.07.028
Myxoma Virus: Propagation, Purification, Quantification, and Storage
Myxoma and vaccinia viruses exploit different mechanisms to enter and infect human cancer cells
Nancy Y. Villa, Eric Bartee, Mohamed R. Mohamed, Masmudur M. Rahman, John W. Barrett and Grant McFadden Virology 401(2) 266 (2010) https://doi.org/10.1016/j.virol.2010.02.027
Host-specificity of myxoma virus: Pathogenesis of South American and North American strains of myxoma virus in two North American lagomorph species
The Myxoma Virus M-T5 Ankyrin Repeat Host Range Protein Is a Novel Adaptor That Coordinately Links the Cellular Signaling Pathways Mediated by Akt and Skp1 in Virus-Infected Cells
The Addition of Tumor Necrosis Factor plus Beta Interferon Induces a Novel Synergistic Antiviral State against Poxviruses in Primary Human Fibroblasts
Eric Bartee, Mohamed R. Mohamed, M. Cecilia Lopez, Henry V. Baker and Grant McFadden Journal of Virology 83(2) 498 (2009) https://doi.org/10.1128/JVI.01376-08
M148R and M149R are two virulence factors for myxoma virus pathogenesis in the European rabbit
Sophie Blanié, Jérémy Mortier, Maxence Delverdier, Stéphane Bertagnoli and Christelle Camus-Bouclainville Veterinary Research 40(1) 11 (2009) https://doi.org/10.1051/vetres:2008049
The role of cell signaling in poxvirus tropism: The case of the M-T5 host range protein of myxoma virus
A pathogenic myxoma virus in vaccinated and non-vaccinated commercial rabbits
S.K. Kritas, C. Dovas, P. Fortomaris, E. Petridou, A. Farsang and G. Koptopoulos Research in Veterinary Science 85(3) 622 (2008) https://doi.org/10.1016/j.rvsc.2008.03.008
Characterisation of immunosuppression in rabbits after infection with myxoma virus
Construction and testing of a novel host-range defective myxoma virus vaccine with the M063 gene inactivated that is non-permissive for replication in rabbit cells
Myxoma Virus Expressing Human Interleukin-12 Does Not Induce Myxomatosis in European Rabbits
Marianne M. Stanford, John W. Barrett, Philippe-Alexandre Gilbert, Richard Bankert and Grant McFadden Journal of Virology 81(22) 12704 (2007) https://doi.org/10.1128/JVI.01483-07
Myxoma virus and oncolytic virotherapy: a new biologic weapon in the war against cancer