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Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field
Sara Canoyra, Alba Marín-Moreno, Juan Carlos Espinosa, Natalia Fernández-Borges, Enric Vidal, Leonor Orge, Sylvie L. Benestad, Olivier Andréoletti and Juan María Torres Proceedings of the National Academy of Sciences 122(29) (2025) https://doi.org/10.1073/pnas.2501104122
In silico study of structure-based screening of inhibitors to block PrPC conversion and amyloid aggregation
Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination
A. Marín-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue, D. Martin and Isaac H. Solomon Microbiology Spectrum (2025) https://doi.org/10.1128/spectrum.00292-25
Species barrier as molecular basis for adaptation of synthetic prions with N‐terminally truncated PrP
Human Rezaei, Davy Martin, Laetitia Herzog, Fabienne Reine, Alba Marín Moreno, Mohammed Moudjou, Naima Aron, Angélique Igel, Hannah Klute, Stella Youssafi, Jean‐Baptiste Moog, Pierre Sibille, Olivier Andréoletti, Joan Torrent and Vincent Béringue The FEBS Journal 291(22) 5051 (2024) https://doi.org/10.1111/febs.17291
The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics
Basile Fornara, Angélique Igel, Vincent Béringue, Davy Martin, Pierre Sibille, Laurent Pujo-Menjouet and Human Rezaei iScience 27(12) 111381 (2024) https://doi.org/10.1016/j.isci.2024.111381
Characterisation of European Field Goat Prion Isolates in Ovine PrP Overexpressing Transgenic Mice (Tgshp IX) Reveals Distinct Prion Strains
Sonja Ernst, Romolo Nonno, Jan Langeveld, Olivier Andreoletti, Cristina Acin, Penelope Papasavva-Stylianou, Theodoros Sklaviadis, Pier Luigi Acutis, Lucien van Keulen, John Spiropoulos, Markus Keller, Martin H. Groschup and Christine Fast Pathogens 13(8) 629 (2024) https://doi.org/10.3390/pathogens13080629
Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution
Erez Harpaz, Federico Angelo Cazzaniga, Linh Tran, Tram T. Vuong, Giuseppe Bufano, Øyvind Salvesen, Maiken Gravdal, Devin Aldaz, Julianna Sun, Sehun Kim, Luigi Celauro, Giuseppe Legname, Glenn C. Telling, Michael A. Tranulis, Sylvie L. Benestad, Arild Espenes, Fabio Moda and Cecilie Ersdal Veterinary Research 55(1) (2024) https://doi.org/10.1186/s13567-024-01350-6
Characterization of the First Case of Classical Scrapie in a Sheep in Tunisia
Abdelkader Amara, Kéfia Elmehatli, Michele Angelo Di Bari, Laura Pirisinu, Rihab Andolsi, Souhir Gachout, Boubaker Ben Smida, Meriem Handous, Heni Haj Ammar, Roukaya Khorchani, Malek Zrelli, Barbara Iulini, Caterina Lucia Florio, Maria Caramelli, Cristina Casalone, Laura De Antoniis, Geraldina Riccardi, Elena Esposito, Matteo Giovannelli, Claudia D’Agostino, Barbara Chiappini, Romolo Nonno, Umberto Agrimi, Gabriele Vaccari and Daniel Diaz Transboundary and Emerging Diseases 2023 1 (2023) https://doi.org/10.1155/2023/2253316
Prion assemblies: structural heterogeneity, mechanisms of formation, and role in species barrier
Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification
Erez Harpaz, Tram Thu Vuong, Linh Tran, Michael Andreas Tranulis, Sylvie L. Benestad and Cecilie Ersdal Veterinary Research 54(1) (2023) https://doi.org/10.1186/s13567-023-01220-7
Human Rezaei, Davy Martin, Laetitia Herzog, Fabienne Reine, Naima Aron, Angélique Igel, Hannah Klute, Stella Youssafi, Jean-Baptiste Moog, Pierre Sibille, Olivier Andréoletti, Joan Torrent and Vincent Béringue (2023) https://doi.org/10.1101/2023.02.27.530231
Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Fiona Sailler, Hannah Klute, Frederic Halgand, Guillaume Van der Rest, Yves Boulard, Vincent Béringue, Angelique Igel and Human Rezaei (2023) https://doi.org/10.1101/2023.03.21.533631
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Alba Marín-Moreno, Sara Canoyra, Natalia Fernández-Borges, Juan Carlos Espinosa and Juan María Torres Frontiers in Bioscience-Landmark 28(1) (2023) https://doi.org/10.31083/j.fbl2801021
The Smallest Infectious Substructure Encoding the Prion Strain Structural Determinant Revealed by Spontaneous Dissociation of Misfolded Prion Protein Assemblies
Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Fiona Sailer, Hannah Klute, Frederic Halgand, Guillaume Van der Rest, Yves Boulard, Vincent Béringue, Angelique Igel and Human Rezaei Journal of Molecular Biology 435(21) 168280 (2023) https://doi.org/10.1016/j.jmb.2023.168280
Variation in the PRNP gene of Pere David’s deer (Elaphurus davidianus) may impact genetic vulnerability to chronic wasting disease
Strain Typing of Classical Scrapie and Bovine Spongiform Encephalopathy (BSE) by Using Ovine PrP (ARQ/ARQ) Overexpressing Transgenic Mice
Olanrewaju I. Fatola, Markus Keller, Anne Balkema-Buschmann, James Olopade, Martin H. Groschup and Christine Fast International Journal of Molecular Sciences 23(12) 6744 (2022) https://doi.org/10.3390/ijms23126744
Prion potentiation after life-long dormancy in mice devoid of PrP
Porcine Prion Protein as a Paradigm of Limited Susceptibility to Prion Strain Propagation
Juan Carlos Espinosa, Alba Marín-Moreno, Patricia Aguilar-Calvo, et al. The Journal of Infectious Diseases 223(6) 1103 (2021) https://doi.org/10.1093/infdis/jiz646
Met166‐Glu168 residues in human PrP β2‐α2 loop account for evolutionary resistance to prion infection
Prions from Sporadic Creutzfeldt-Jakob Disease Patients Propagate as Strain Mixtures
Hervé Cassard, Alvina Huor, Juan-Carlos Espinosa, et al. mBio 11(3) (2020) https://doi.org/10.1128/mBio.00393-20
Angélique Igel-Egalon, Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Juan Maria Torres, Hubert Laude, Human Rezaei and Vincent Béringue (2019) https://doi.org/10.1101/861278
Angélique Igel-Egalon, Florent Laferrière, Mohammed Moudjou, Mathieu Merzach, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Marie Doumic, Human Rezaei and Vincent Béringue (2019) https://doi.org/10.1101/583781
Nucleotide structure of prion protein gene in Egyptian camels
Sekena H. Abdel-Aziem, Heba A. M. Abd El-Kader, Sally S. Alam, Omaima M. Abd El-Moneim and Othman E. Othman Journal of Applied Animal Research 47(1) 123 (2019) https://doi.org/10.1080/09712119.2019.1580584
Animal prion diseases: the risks to human health
Fiona Houston and Olivier Andréoletti Brain Pathology 29(2) 248 (2019) https://doi.org/10.1111/bpa.12696
Vincent Béringue, Philippe Tixador, Olivier Andréoletti, Fabienne Reine, Johan Castille, Thanh-Lan Laï, Annick Le Dur, Aude Laisné, Laetitia Herzog, Bruno Passet, Human Rezaei, Jean-Luc Vilotte and Hubert Laude (2019) https://doi.org/10.1101/2019.12.17.879676
Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway
The emergence of classical BSE from atypical/Nor98 scrapie
Alvina Huor, Juan Carlos Espinosa, Enric Vidal, et al. Proceedings of the National Academy of Sciences 116(52) 26853 (2019) https://doi.org/10.1073/pnas.1915737116
Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?
Angélique Igel-Egalon, Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Human Rezaei and Vincent Béringue Viruses 11(5) 429 (2019) https://doi.org/10.3390/v11050429
Transition of the prion protein from a structured cellular form (PrPC) to the infectious scrapie agent (PrPSc)
Pravas K. Baral, Jiang Yin, Adriano Aguzzi and Michael N. G. James Protein Science 28(12) 2055 (2019) https://doi.org/10.1002/pro.3735
Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
Presumptive BSE cases with an aberrant prion protein phenotype in Switzerland, 2011: Lack of prion disease in experimentally inoculated cattle and bovine prion protein transgenic mice
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions
Absence of Evidence for a Causal Link between Bovine Spongiform Encephalopathy Strain Variant L-BSE and Known Forms of Sporadic Creutzfeldt-Jakob Disease in Human PrP Transgenic Mice
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells
X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins
Pravas Kumar Baral, Mridula Swayampakula, Adriano Aguzzi and Michael N.G. James Journal of Structural Biology 192(1) 37 (2015) https://doi.org/10.1016/j.jsb.2015.08.014