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Classical BSE emergence from Nor98/atypical scrapie: Unraveling the shift vs. selection dichotomy in the prion field
Sara Canoyra, Alba Marín-Moreno, Juan Carlos Espinosa, Natalia Fernández-Borges, Enric Vidal, Leonor Orge, Sylvie L. Benestad, Olivier Andréoletti and Juan María Torres Proceedings of the National Academy of Sciences 122(29) (2025) https://doi.org/10.1073/pnas.2501104122
Human PrP E219K: a new and promising substrate for robust RT-QuIC amplification of human prions with potential for strain discrimination
In silico study of structure-based screening of inhibitors to block PrPC conversion and amyloid aggregation
Kamakshi Ruhela, Subham, Shailendra S. Maurya, Hemlata Dwivedi-Agnihotri and Sumit K. Chaturvedi Frontiers in Chemical Biology 4 (2025) https://doi.org/10.3389/fchbi.2025.1736396
Overview of North American Isolates of Chronic Wasting Disease Used for Strain Research
Characterisation of European Field Goat Prion Isolates in Ovine PrP Overexpressing Transgenic Mice (Tgshp IX) Reveals Distinct Prion Strains
Sonja Ernst, Romolo Nonno, Jan Langeveld, Olivier Andreoletti, Cristina Acin, Penelope Papasavva-Stylianou, Theodoros Sklaviadis, Pier Luigi Acutis, Lucien van Keulen, John Spiropoulos, Markus Keller, Martin H. Groschup and Christine Fast Pathogens 13(8) 629 (2024) https://doi.org/10.3390/pathogens13080629
Species barrier as molecular basis for adaptation of synthetic prions with N‐terminally truncated PrP
Human Rezaei, Davy Martin, Laetitia Herzog, Fabienne Reine, Alba Marín Moreno, Mohammed Moudjou, Naima Aron, Angélique Igel, Hannah Klute, Stella Youssafi, Jean‐Baptiste Moog, Pierre Sibille, Olivier Andréoletti, Joan Torrent and Vincent Béringue The FEBS Journal 291(22) 5051 (2024) https://doi.org/10.1111/febs.17291
Basile Fornara, Angélique Igel, Vincent Béringue, Davy Martin, Pierre Sibille, Laurent Pujo-Menjouet and Human Rezaei (2024) https://doi.org/10.1101/2024.05.01.592001
The dynamics of prion spreading is governed by the interplay between the non-linearities of tissue response and replication kinetics
Basile Fornara, Angélique Igel, Vincent Béringue, Davy Martin, Pierre Sibille, Laurent Pujo-Menjouet and Human Rezaei iScience 27(12) 111381 (2024) https://doi.org/10.1016/j.isci.2024.111381
Transmission of Norwegian reindeer CWD to sheep by intracerebral inoculation results in an unusual phenotype and prion distribution
Erez Harpaz, Federico Angelo Cazzaniga, Linh Tran, Tram T. Vuong, Giuseppe Bufano, Øyvind Salvesen, Maiken Gravdal, Devin Aldaz, Julianna Sun, Sehun Kim, Luigi Celauro, Giuseppe Legname, Glenn C. Telling, Michael A. Tranulis, Sylvie L. Benestad, Arild Espenes, Fabio Moda and Cecilie Ersdal Veterinary Research 55(1) (2024) https://doi.org/10.1186/s13567-024-01350-6
A. Marin-Moreno, F. Reine, F. Jaffrézic, L. Herzog, H. Rezaei, I. Quadrio, S. Haïk, V. Béringue and D. Martin (2024) https://doi.org/10.1101/2024.07.31.605973
Inter- and intra-species conversion efficacies of Norwegian prion isolates estimated by serial protein misfolding cyclic amplification
Erez Harpaz, Tram Thu Vuong, Linh Tran, Michael Andreas Tranulis, Sylvie L. Benestad and Cecilie Ersdal Veterinary Research 54(1) (2023) https://doi.org/10.1186/s13567-023-01220-7
Human Rezaei, Davy Martin, Laetitia Herzog, Fabienne Reine, Naima Aron, Angélique Igel, Hannah Klute, Stella Youssafi, Jean-Baptiste Moog, Pierre Sibille, Olivier Andréoletti, Joan Torrent and Vincent Béringue (2023) https://doi.org/10.1101/2023.02.27.530231
Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Fiona Sailler, Hannah Klute, Frederic Halgand, Guillaume Van der Rest, Yves Boulard, Vincent Béringue, Angelique Igel and Human Rezaei (2023) https://doi.org/10.1101/2023.03.21.533631
Transgenic Mouse Models for the Study of Neurodegenerative Diseases
Alba Marín-Moreno, Sara Canoyra, Natalia Fernández-Borges, Juan Carlos Espinosa and Juan María Torres Frontiers in Bioscience-Landmark 28(1) (2023) https://doi.org/10.31083/j.fbl2801021
The Smallest Infectious Substructure Encoding the Prion Strain Structural Determinant Revealed by Spontaneous Dissociation of Misfolded Prion Protein Assemblies
Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Fiona Sailer, Hannah Klute, Frederic Halgand, Guillaume Van der Rest, Yves Boulard, Vincent Béringue, Angelique Igel and Human Rezaei Journal of Molecular Biology 435(21) 168280 (2023) https://doi.org/10.1016/j.jmb.2023.168280
Strain Typing of Classical Scrapie and Bovine Spongiform Encephalopathy (BSE) by Using Ovine PrP (ARQ/ARQ) Overexpressing Transgenic Mice
Olanrewaju I. Fatola, Markus Keller, Anne Balkema-Buschmann, James Olopade, Martin H. Groschup and Christine Fast International Journal of Molecular Sciences 23(12) 6744 (2022) https://doi.org/10.3390/ijms23126744
Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases
Met166‐Glu168 residues in human PrP β2‐α2 loop account for evolutionary resistance to prion infection
Juan Carlos Espinosa, Alba Marín‐Moreno, Patricia Aguilar‐Calvo and Juan María Torres Neuropathology and Applied Neurobiology 47(4) 506 (2021) https://doi.org/10.1111/nan.12676
Allelic Interference in Prion Replication Is Modulated by the Convertibility of the Interfering PrP
C
and Other Host-Specific Factors
Porcine Prion Protein as a Paradigm of Limited Susceptibility to Prion Strain Propagation
Juan Carlos Espinosa, Alba Marín-Moreno, Patricia Aguilar-Calvo, et al. The Journal of Infectious Diseases 223(6) 1103 (2021) https://doi.org/10.1093/infdis/jiz646
Prion potentiation after life-long dormancy in mice devoid of PrP
Nucleotide structure of prion protein gene in Egyptian camels
Sekena H. Abdel-Aziem, Heba A. M. Abd El-Kader, Sally S. Alam, Omaima M. Abd El-Moneim and Othman E. Othman Journal of Applied Animal Research 47(1) 123 (2019) https://doi.org/10.1080/09712119.2019.1580584
Angélique Igel-Egalon, Florent Laferrière, Mohammed Moudjou, Mathieu Merzach, Tina Knäpple, Laetitia Herzog, Fabienne Reine, Marie Doumic, Human Rezaei and Vincent Béringue (2019) https://doi.org/10.1101/583781
Early stage prion assembly involves two subpopulations with different quaternary structures and a secondary templating pathway
Angélique Igel-Egalon, Florent Laferrière, Mohammed Moudjou, et al. Communications Biology 2(1) (2019) https://doi.org/10.1038/s42003-019-0608-y
Vincent Béringue, Philippe Tixador, Olivier Andréoletti, Fabienne Reine, Johan Castille, Thanh-Lan Laï, Annick Le Dur, Aude Laisné, Laetitia Herzog, Bruno Passet, Human Rezaei, Jean-Luc Vilotte and Hubert Laude (2019) https://doi.org/10.1101/2019.12.17.879676
Review: Update on Classical and Atypical Scrapie in Sheep and Goats
Use of different RT-QuIC substrates for detecting CWD prions in the brain of Norwegian cervids
Edoardo Bistaffa, Tram Thu Vuong, Federico Angelo Cazzaniga, et al. Scientific Reports 9(1) (2019) https://doi.org/10.1038/s41598-019-55078-x
Angélique Igel-Egalon, Florent Laferrière, Philippe Tixador, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Juan Maria Torres, Hubert Laude, Human Rezaei and Vincent Béringue (2019) https://doi.org/10.1101/861278
The emergence of classical BSE from atypical/Nor98 scrapie
Alvina Huor, Juan Carlos Espinosa, Enric Vidal, et al. Proceedings of the National Academy of Sciences 116(52) 26853 (2019) https://doi.org/10.1073/pnas.1915737116
Heterogeneity and Architecture of Pathological Prion Protein Assemblies: Time to Revisit the Molecular Basis of the Prion Replication Process?
Angélique Igel-Egalon, Jan Bohl, Mohammed Moudjou, Laetitia Herzog, Fabienne Reine, Human Rezaei and Vincent Béringue Viruses 11(5) 429 (2019) https://doi.org/10.3390/v11050429
Prion replication environment defines the fate of prion strain adaptation
Presumptive BSE cases with an aberrant prion protein phenotype in Switzerland, 2011: Lack of prion disease in experimentally inoculated cattle and bovine prion protein transgenic mice
Protein Misfolding Cyclic Amplification Cross-Species Products of Mouse-Adapted Scrapie Strain 139A and Hamster-Adapted Scrapie Strain 263K with Brain and Muscle Tissues of Opposite Animals Generate Infectious Prions
Absence of Evidence for a Causal Link between Bovine Spongiform Encephalopathy Strain Variant L-BSE and Known Forms of Sporadic Creutzfeldt-Jakob Disease in Human PrP Transgenic Mice
The role of the unusual threonine string in the conversion of prion protein
Romany Abskharon, Fei Wang, Kayla J. Vander Stel, Kumar Sinniah and Jiyan Ma Scientific Reports 6(1) (2016) https://doi.org/10.1038/srep38877
Caprine PrP variants harboring Asp-146, His-154 and Gln-211 alleles display reduced convertibility upon interaction with pathogenic murine prion protein in scrapie infected cells
X-ray structural and molecular dynamical studies of the globular domains of cow, deer, elk and Syrian hamster prion proteins
Pravas Kumar Baral, Mridula Swayampakula, Adriano Aguzzi and Michael N.G. James Journal of Structural Biology 192(1) 37 (2015) https://doi.org/10.1016/j.jsb.2015.08.014
Acquired transmissibility of sheep-passaged L-type bovine spongiform encephalopathy prion to wild-type mice