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Figure 2.


siRNA synthesized in vivo induce antiviral response in suckling mice and promote survival after FMDV infection. Suckling mice were challenged by subcutaneous injection in the neck with 20 LD50 of HKN/2002 (A) or 20 LD50 of YNBS/58 (B) after 6 h of treatment with either control plasmids or FMDV-specific siRNA-expressing plasmids. All animals were observed for 6 days after challenge.

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