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Figure 3.

Discriminatory immunohistochemistry on an unusual goat TSE case. Extracellular accumulation of PrPd in the brain was revealed with both Bar224 (a) and 12B2 (b) PrP antibodies. IHC and haematoxylin counterstaining, ×4. Intraneuronal PrPd deposits in the olivary nucleus were prominent when labelled with Bar224 (c) but absent when incubated with 12B2 antibody (d). IHC and haematoxylin counterstaining, ×20. In the retropharyngeal lymph node, however, intracellular PrPd deposits were labelled with both bar224 (e) and 12B2 (f) antibodies. IHC and haematoxylin counterstaining, ×10.