Replenishment of IL-12 and IFN-γ reverts susceptibility of MyD88^−/− mice to acute N. caninum infection. Survival curves of (A) WT, IL-12p40^−/−, MyD88^−/− and MyD88^−/− mice treated with rIL-12p70 or (B) WT, IFNγ^−/−, MyD88^−/− and MyD88^−/− mice treated with rIFNγ (n = 6 mice/group), infected at the same time with sub-lethal parasite doses. Survival was observed through a 30-day period. Data are representative of two independent experiments.