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Figure 4.

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Antigen presenting cells from MyD88−/− mice are unable to produce IL-12, despite their intact migration pattern. (A) Immunophenotyping of potential IL-12+ cells to the peritoneal cavity at 3, 7, and 10 days p.i. (n = 3 mice/group/date), determined by flow cytometry analysis of cell surface markers. Data are representative of two independent experiments. (B) Intracellular IL-12 staining of immunophenotyped APC present in the peritoneal cavity of uninfected WT and MyD88−/− and after 3 days p.i. The results show one representative animal of a total from three of each group/date. * Indicates significant statistical differences (mean ± SEM, p < 0.05).

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