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Table II.
Activity and predicted function of novel tick genes identified from uninfected and Rickettsia-infected D. variabilis using molecular techniques.
| Predicted function | Putative identification | Expression during rickettsial infection |
|---|---|---|
| Adhesion or invasion | Mucin-like protein | --- |
| Clathrin adaptor protein | +++ | |
| Tetraspanin | +++ | |
| Protein inhibitor of signal transducer and activator of transcription 1/3 | --- | |
| ATPase of clathrin-coated vesicles | +++ | |
| Catenin | +++ | |
| Tick immune and stress response | Ferritin | +++ |
| α-dehydrogenase reductase | +++ | |
| Glutathione S-transferase | +++ | |
| Nucleosome assembly protein | +++ | |
| Cyclin A2 protein | +++ | |
| Cu2+-transporting ATPase | +++ | |
| Tubulin α chain | +++ | |
| Defensin | -/+ | |
| Lysozyme | + | |
| Serine protease | NS | |
| Prophenoloxidase-activating factor | +++ | |
| Tick-host interactions | α-2 macroglobulin | +++ |
| Salivary glue precursor | +++ | |
| IgE-dependent histamine release factor | +++ | |
| ENA vasodilator | +++ | |
| Calreticulin | --- | |
| Histamine release factor | +++ | |
| Unknown | Probable elongation factor | +++ |
| Similar to Drosophila melanogaster CG17525 | +++ | |
| Glycine-rich protein | +++ |
NS: Not studied.