Free Access
Table I.
Survival data and mean incubation periods of RIII and C57bl mice inoculated i.c./i.p. with tissues pooled from cattle at time intervals after the cattle were orally dosed with 100 g of BSE affected brain stem homogenate [32]. Data for tissues and time intervals where transmissions were negative are omitted.
| Tissue | Time post exposure (months) | RIII |
C57bl |
||
|---|---|---|---|---|---|
| No. of mice +ve/No. of mice surviving when first mouse confirmed +ve | Mean incubation period (days) (SEM) | No. of mice +ve/No. of mice surviving when first mouse confirmed +ve | Mean incubation period (days) (SEM) | ||
| Distal ileum | 6 | 10/12 | 523.7 (17.5) | – | – |
| 10 | 14/17 | 511.4 (15.2) | – | – | |
| 14 | 15/18 | 455.0 (12.8) | – | – | |
| 18 | 18/18 | 470.7 (12.3) | – | – | |
| 36 | 0/10 | N/A | 1/2 | 942.0 (−) | |
| 38 | 4/14 | 581.5 (33.2) | 4/12 | 791.3 (48.8) | |
| 40 | 14/17 | 538.2 (16.9) | 8/19 | 644.4 (32.8) | |
| Caudal medulla | 32 | 6/17 | 584.9 (24.9) | 7/16 | 743 (33.4) |
| 36 | 7/14 | 554.9 (19.2) | 12/19 | 707 (24.2) | |
| 38 | 14/18 | 486.9 (18.1) | 14/19 | 608.3 (37.2) | |
| 40 | 11/12 | 485.0 (12.8) | 14/20 | 637.5 (34.7) | |
| Cervical spinal cord (C2–3) | 32 | 2/16 | 596.0 (57.0) | 6/20 | 840.8 (38.7) |
| 36 | 5/13 | 565.4 (28.3) | 7/14 | 733.9 (19) | |
| 38 | 10/17 | 555.1 (18.7) | 9/19 | 675.4 (24.5) | |
| 40 | 16/20 | 477.6 (10.8) | 11/16 | 687.1 (27.7) | |
| Thoracic spinal cord (T10–11) | 32 | 2/15 | 523.0 (74.0) | 8/19 | 787.4 (44.1) |
| 36 | 15/19 | 554.5 (13.8) | 13/18 | 716.2 (21.7) | |
| 38 | 8/17 | 576.2 (15.6) | 6/19 | 703.2 (52.4) | |
| 40 | 13/18 | 457.5 (11.7) | 14/19 | 627.6 (25.4) | |
| Lumbar spinal cord (L3–4) | 32 | 3/15 | 570.0 (39.8) | 9/19 | 730.6 (32.8) |
| 36 | 9/15 | 523.7 (15.2) | 11/19 | 670.8 (28.9) | |
| 38 | 13/16 | 526.2 (16.2) | 15/20 | 659.7 (25.7) | |
| 40 | 16/18 | 485.5 (13.7) | 11/17 | 666.3 (32.5) | |
| Frontal cortex | 36 | 1/12 | 552.0 (−) | 0/4 | N/A |
| 38 | 1/10 | 642.0 (−) | 2/18 | 690.5 (135.5) | |
| 40 | 10/14 | 568.0 (18.5) | 7/14 | 837.3 (38.3) | |
| Thoracic DRG (T5–8) | 32 | 3/18 | 541.7 (42.8) | 3/10 | 807.3 (38.4) |
| 36 | 8/20 | 531.9 (25.1) | 9/18 | 654.4 (22.5) | |
| 38 | 0/7 | N/A | 1/18 | 614.0 (−) | |
| 40 | 9/20 | 587.6 (20.7) | 4/14 | 754.8 (32.5) | |
| Cervical DRG (C3–6) | 32 | 0/8 | N/A | 1/10 | 817.0 (−) |
| 36 | 4/17 | 553.2 (33.3) | 3/16 | 722.3 (8.5) | |
| 38 | 1/15 | 552.0 (−) | 0/3 | N/A | |
| 40 | 1/9 | 652.0 (−) | 0/3 | N/A | |
| Trigeminal ganglion | 36 | 0/14 | N/A | 2/18 | 570 (70) |
| 38 | 3/13 | 520.7 (24.8) | 3/16 | 722 (55) | |
| 40 | 4/14 | 548.5 (41.9) | 1/2 | 894.0 (−) | |