Free access article

Issue Vet. Res. Volume 35, Number 2, March-April 2004 Page(s) 149 - 161 DOI 10.1051/vetres:2004007

Vet. Res. 35 (2004) 149-161
DOI: 10.1051/vetres:2004007

DNA vaccination against Chlamydiaceae: current status and perspectives

Céline Héchard and Olivier Grépinet

Unité de Pathologie Infectieuse et Immunologie, INRA-Centre de Tours, 37380 Nouzilly, France
(Received 27 August 2003; accepted 7 October 2003)

Abstract - DNA vaccination (also called genetic vaccination) recently celebrated its ten years of existence. This new method of immunization presents several advantages, including the induction of both humoral and cellular immune responses. This vaccination strategy has been very successful and has served as a basis for numerous experiments that had the aim of resolving parasitic, viral, and bacterial infections. In particular, DNA vaccination has been evaluated against Chlamydiaceae, small obligate intracellular bacteria, that induce many pathologies in humans and animals. Despite promising protective effects obtained in murine and turkey models with genes encoding outer membrane proteins and heat shock proteins, DNA vaccination against Chlamydiaceae must be optimized by further investigations and could benefit from the genomic sequencing in terms of the identification of new antigens.

Key words: DNA vaccination / Chlamydia / Chlamydophila

Corresponding author: Olivier Grépinet grepinet@tours.inra.fr

© INRA, EDP Sciences 2004

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